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Tbio
LIAS
Lipoyl synthase, mitochondrial

Protein Summary
Description
Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. The protein encoded by this gene belongs to the biotin and lipoic acid synthetases family. It localizes in mitochondrion and plays an important role in alpha-(+)-lipoic acid synthesis. It may also function in the sulfur insertion chemistry in lipoate biosynthesis. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340169
  • ENSP00000340676
  • ENSG00000121897
  • ENST00000381846
  • ENSP00000371270
  • ENST00000640888
  • ENSP00000492260

Symbol
  • LAS
  • LS
  • LAS
  • LIP1
  • PDHLD
  • HGCLAS
  • HUSSY-01
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.8
transcription factor binding site profile
0.78
tissue sample
0.75
molecular function
0.6
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.73   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.73   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (132)
GCSH
Tbio
Novelty:  0.02101972
p_int:  0.999546541
p_ni:  1.1e-8
p_wrong:  0.000453448
Score:  0.978
Data Source:  BioPlex,Reactome,STRINGDB
LIPT2
Tbio
Family:  Enzyme
Novelty:  0.31022396
Score:  0.992
Data Source:  STRINGDB
LIPT1
Tdark
Family:  Enzyme
Novelty:  0.0546324
Score:  0.99
Data Source:  STRINGDB
ISCA2
Tbio
Novelty:  0.02194373
Score:  0.908
Data Source:  STRINGDB
NFU1
Tbio
Novelty:  0.01465025
Score:  0.903
Data Source:  STRINGDB
OXSM
Tbio
Family:  Enzyme
Novelty:  0.00615894
Score:  0.895
Data Source:  STRINGDB
ISCA1
Tbio
Novelty:  0.01288069
Score:  0.887
Data Source:  STRINGDB
IBA57
Tbio
Family:  Enzyme
Novelty:  0.06327415
Score:  0.887
Data Source:  STRINGDB
BOLA3
Tbio
Novelty:  0.06292339
Score:  0.865
Data Source:  STRINGDB
ISCU
Tbio
Novelty:  0.0043097
Score:  0.833
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Glyoxylate metabolism and glycine degradation (R-HSA-389661)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glyoxylate metabolism and glycine degradation
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Glyoxylate metabolism and glycine degradation
Metabolism
Metabolism of amino acids and derivatives
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
13
10
18
8.1
99.6
alcohol use disorder measurement
5
5
2
7.9
99
longitudinal alcohol consumption measurement
1
1
1
87.7
blood urea nitrogen measurement
2
2
2
85.4
bitter alcoholic beverage consumption measurement
1
1
1
82.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
18
8.1
99.6
alcohol use disorder measurement
2
7.9
99
longitudinal alcohol consumption measurement
1
87.7
blood urea nitrogen measurement
2
85.4
bitter alcoholic beverage consumption measurement
1
82.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lipoic acid synthetase
VGNC:750
471170
Macaque
lipoic acid synthetase
699244
Mouse
MGI:1934604
79464
Rat
RGD:1307270
305348
Dog
lipoic acid synthetase
VGNC:42670
479108
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lipoic acid synthetase
Macaque
lipoic acid synthetase
Mouse
Rat
Dog
lipoic acid synthetase
Publication Statistics
PubMed Score 95.73
PubMed score by year
PubTator Score 56.19
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title