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Tbio
LHX4
LIM/homeobox protein Lhx4

Protein Summary
Description
May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Binds preferentially to methylated DNA (PubMed:28473536). This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor involved in the control of differentiation and development of the pituitary gland. Mutations in this gene cause combined pituitary hormone deficiency 4. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263726
  • ENSP00000263726
  • ENSG00000121454

Symbol
  • CPHD4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.7
histone modification site profile
0.61
cell line
0.6
biological process
0.59
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.86   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 344   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.86   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 344   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (80)
SSBP4
Tdark
Novelty:  0.27365687
p_int:  0.999999987
p_ni:  1.3e-8
Score:  0.766
Data Source:  BioPlex,STRINGDB
SMAD4
Tbio
Family:  TF
Novelty:  0.00047069
p_int:  0.999999798
p_wrong:  2.02e-7
Score:  0.344
Data Source:  BioPlex,STRINGDB
LDB1
Tbio
Novelty:  0.01110112
p_int:  0.999947729
p_ni:  0.000052271
Score:  0.983
Data Source:  BioPlex,Reactome,STRINGDB
SSBP2
Tbio
Novelty:  0.06546999
p_int:  0.999721619
p_ni:  0.00027838
p_wrong:  1e-9
Score:  0.752
Data Source:  BioPlex,STRINGDB
CETN1
Tbio
Novelty:  0.01208917
p_int:  0.999577823
p_ni:  0.00001055
p_wrong:  0.000411628
Data Source:  BioPlex
THAP12
Tbio
Family:  TF
Novelty:  0.21092098
p_int:  0.999356819
p_ni:  0.000643181
Score:  0.518
Data Source:  BioPlex,STRINGDB
ISL2
Tbio
Family:  TF
Novelty:  0.03917372
p_int:  0.999311138
p_ni:  0.000687985
p_wrong:  8.78e-7
Score:  0.865
Data Source:  BioPlex,STRINGDB
CHMP1A
Tbio
Novelty:  0.03969333
p_int:  0.983208204
p_ni:  0.001817604
p_wrong:  0.014974192
Data Source:  BioPlex
WASF2
Tbio
Novelty:  0.00968798
p_int:  0.979158324
p_ni:  0.009618184
p_wrong:  0.011223492
Score:  0.237
Data Source:  BioPlex,STRINGDB
TSC22D4
Tbio
Family:  TF
Novelty:  0.25451456
p_int:  0.978397921
p_ni:  0.021594689
p_wrong:  0.000007391
Score:  0.74
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Regulation of expression of SLITs and ROBOs
Reactome
Signaling by ROBO receptors
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Regulation of expression of SLITs and ROBOs
Signaling by ROBO receptors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred by Curator (IC)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
1
1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
58.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LIM homeobox 4
VGNC:10707
469601
Mouse
MGI:101776
16872
Rat
RGD:1308044
360858
Dog
LIM homeobox 4
VGNC:42665
490300
Horse
LIM homeobox 4
VGNC:19658
100051084
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LIM homeobox 4
Mouse
Rat
Dog
LIM homeobox 4
Horse
LIM homeobox 4
Publication Statistics
PubMed Score 49.86
PubMed score by year
PubTator Score 39.01
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title