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Tbio
LGR6
Leucine-rich repeat-containing G-protein coupled receptor 6

Protein Summary
Description
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor. This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. [provided by R ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000255432
  • ENSP00000255432
  • ENSG00000133067
  • ENST00000367278
  • ENSP00000356247
  • ENST00000439764
  • ENSP00000387869

Symbol
  • GPCR
  • VTS20631
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein)
0.85
protein domain
0.73
transcription factor binding site profile
0.7
cell type or tissue
0.67
PubMedID
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.71   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 320   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.71   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 320   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
RSPO1
Tbio
Novelty:  0.00365075
Score:  0.974
Data Source:  Reactome,STRINGDB
RSPO3
Tbio
Novelty:  0.02321039
Score:  0.969
Data Source:  Reactome,STRINGDB
RSPO4
Tbio
Novelty:  0.05670413
Score:  0.968
Data Source:  Reactome,STRINGDB
RSPO2
Tbio
Novelty:  0.0188211
Score:  0.967
Data Source:  Reactome,STRINGDB
ZNRF3
Tbio
Family:  Enzyme
Novelty:  0.03351825
Score:  0.96
Data Source:  Reactome,STRINGDB
RNF43
Tbio
Family:  Enzyme
Novelty:  0.01258908
Score:  0.955
Data Source:  Reactome,STRINGDB
LGR4
Tbio
Family:  GPCR
Novelty:  0.01180123
Score:  0.91
Data Source:  STRINGDB
LGR5
Tbio
Family:  GPCR
Novelty:  0.00105035
Score:  0.908
Data Source:  STRINGDB
UBC
Tbio
Novelty:  0.00204643
Score:  0.905
Data Source:  STRINGDB
UBB
Tbio
Novelty:  0.00661254
Score:  0.905
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Regulation of FZD by ubiquitination (R-HSA-4641263)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Regulation of FZD by ubiquitination
Reactome
Signal Transduction
Reactome
Signaling by WNT
Reactome
TCF dependent signaling in response to WNT
Name
Explore in Pharos
Explore in Source
Regulation of FZD by ubiquitination
Signal Transduction
Signaling by WNT
TCF dependent signaling in response to WNT
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
70.8
2
2
0
1.1
65.7
biological sex
1
1
1
63.1
body mass index
1
1
1
57.8
heel bone mineral density
2
3
3
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
70.8
0
1.1
65.7
biological sex
1
63.1
body mass index
1
57.8
heel bone mineral density
3
55.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 59.71
PubMed score by year
PubTator Score 80.72
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title