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Tbio
LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

Protein Summary
Description
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379214
  • ENSP00000368516
  • ENSG00000205213
  • ENST00000389858
  • ENSP00000374508

Symbol
  • GPR48
  • GPR48
  • BNMD17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.95
ligand (protein)
0.85
protein domain
0.85
cell type or tissue
0.77
gene perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.62   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 391   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 116.62   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 391   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
ZDHHC1
Tdark
Family:  Enzyme
Novelty:  0.37323519
p_int:  0.965315184
p_ni:  0.034684815
p_wrong:  1e-9
Data Source:  BioPlex
FAM189A2
Tdark
Novelty:  0.41335428
p_int:  0.936120546
p_ni:  0.063879454
Score:  0.203
Data Source:  BioPlex,STRINGDB
LRRIQ1
Tdark
Novelty:  1.8251367
p_int:  0.910670215
p_ni:  0.089329785
Data Source:  BioPlex
TNFRSF19
Tbio
Novelty:  0.01295599
p_int:  0.881121306
p_ni:  0.118878694
Score:  0.221
Data Source:  BioPlex,STRINGDB
DAAM2
Tbio
Novelty:  0.07318127
p_int:  0.875308865
p_ni:  0.124691135
Score:  0.177
Data Source:  BioPlex,STRINGDB
MANSC1
Tdark
Novelty:  0.91681036
p_int:  0.863756029
p_ni:  0.136243959
p_wrong:  1.2e-8
Data Source:  BioPlex
GPR21
Tdark
Family:  GPCR
Novelty:  0.90865557
p_int:  0.857428925
p_ni:  0.142570978
p_wrong:  9.8e-8
Data Source:  BioPlex
HAVCR2
Tbio
Novelty:  0.00155885
p_int:  0.842932328
p_ni:  0.155976809
p_wrong:  0.001090863
Data Source:  BioPlex
ITM2A
Tbio
Novelty:  0.06374858
p_int:  0.838822383
p_ni:  0.161175173
p_wrong:  0.000002444
Score:  0.166
Data Source:  BioPlex,STRINGDB
RNF19B
Tbio
Family:  Enzyme
Novelty:  0.20054824
p_int:  0.830454386
p_ni:  0.169292926
p_wrong:  0.000252688
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Regulation of FZD by ubiquitination (R-HSA-4641263)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Regulation of FZD by ubiquitination
Reactome
Signal Transduction
Reactome
Signaling by WNT
Reactome
TCF dependent signaling in response to WNT
Name
Explore in Pharos
Explore in Source
Regulation of FZD by ubiquitination
Signal Transduction
Signaling by WNT
TCF dependent signaling in response to WNT
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (31)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
10
10
99.4
balding measurement
1
2
2
82.4
bone density
3
3
7
80.7
1
1
0
1.4
67.9
hair color
1
1
0
1.1
59
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
10
99.4
balding measurement
2
82.4
bone density
7
80.7
0
1.4
67.9
hair color
0
1.1
59
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing G protein-coupled receptor 4
VGNC:7760
451088
Macaque
leucine rich repeat containing G protein-coupled receptor 4
701736
Mouse
MGI:1891468
107515
Rat
RGD:628615
286994
Dog
leucine rich repeat containing G protein-coupled receptor 4
VGNC:42655
476896
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing G protein-coupled receptor 4
Macaque
leucine rich repeat containing G protein-coupled receptor 4
Mouse
Rat
Dog
leucine rich repeat containing G protein-coupled receptor 4
Publication Statistics
PubMed Score 116.62
PubMed score by year
PubTator Score 43.60
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title