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Tbio
LGI4
Leucine-rich repeat LGI family member 4

Protein Summary
Description
Component of Schwann cell signaling pathway(s) that controls axon segregation and myelin formation (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310123
  • ENSP00000312273
  • ENSG00000153902
  • ENST00000591633
  • ENSP00000467784

Symbol
  • LGIL3
  • LGIL3
  • AMCNMY
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
cell line
0.58
tissue
0.58
phenotype
0.48
tissue sample
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.74   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.74   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (23)
ADAM22
Tbio
Family:  Enzyme
Novelty:  0.01981755
Score:  0.982
Data Source:  Reactome,STRINGDB
ADAM23
Tbio
Family:  Enzyme
Novelty:  0.02974247
Score:  0.959
Data Source:  Reactome,STRINGDB
ADAM11
Tbio
Family:  Enzyme
Novelty:  0.122537
Score:  0.959
Data Source:  Reactome,STRINGDB
PLP1
Tbio
Novelty:  0.00129083
Score:  0.56
Data Source:  STRINGDB
ADAM28
Tbio
Family:  Enzyme
Novelty:  0.01239522
Score:  0.537
Data Source:  STRINGDB
FXYD7
Tbio
Family:  IC
Novelty:  0.08820333
Score:  0.502
Data Source:  STRINGDB
LRRC56
Tdark
Novelty:  1.32360532
Score:  0.47
Data Source:  STRINGDB
LRRC46
Tdark
Novelty:  1.159245
Score:  0.466
Data Source:  STRINGDB
CADM4
Tbio
Novelty:  0.05034541
Score:  0.465
Data Source:  STRINGDB
O43687
Tbio
Family:  Enzyme
Novelty:  0.04114095
Score:  0.447
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
LGI-ADAM interactions
Name
Explore in Pharos
Explore in Source
Developmental Biology
LGI-ADAM interactions
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
6
7
11
98.8
calcium measurement
3
5
6
94.7
triglyceride measurement
5
4
6
93.2
sex hormone-binding globulin measurement
9
2
8
10.8
92.9
reticulocyte count
7
3
7
91.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
11
98.8
calcium measurement
6
94.7
triglyceride measurement
6
93.2
sex hormone-binding globulin measurement
8
10.8
92.9
reticulocyte count
7
91.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat LGI family member 4
VGNC:11157
468832
Mouse
MGI:2180197
243914
Rat
RGD:735035
361549
Dog
leucine rich repeat LGI family member 4
VGNC:42653
484582
Horse
leucine rich repeat LGI family member 4
VGNC:19647
100050571
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat LGI family member 4
Mouse
Rat
Dog
leucine rich repeat LGI family member 4
Horse
leucine rich repeat LGI family member 4
Publication Statistics
PubMed Score 13.74
PubMed score by year
PubTator Score 7.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title