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Tchem
LGALS9
Galectin-9

Protein Summary
Description
Binds galactosides (PubMed:18005988). Has high affinity for the Forssman pentasaccharide (PubMed:18005988). Ligand for HAVCR2/TIM3 (PubMed:16286920). Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death (PubMed:16286920). Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (By similarity). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T-helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity). Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation (PubMed:23817958). Expands regulatory T- ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302228
  • ENSP00000306228
  • ENSG00000168961
  • ENST00000313648
  • ENSP00000318214
  • ENST00000395473
  • ENSP00000378856

Symbol
  • HUAT
  • LGALS9A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
biological term
0.8
PubMedID
0.74
tissue
0.6
gene perturbation
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 287   (req: < 5)
Gene RIFs: 135   (req: <= 3)
Antibodies: 552   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 287   (req: >= 5)
Gene RIFs: 135   (req: > 3)
Antibodies: 552   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 48
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (125)
PBK
Tchem
Family:  Kinase
Novelty:  0.00278659
p_int:  0.999999447
p_ni:  2e-9
p_wrong:  5.51e-7
Score:  0.219
Data Source:  BioPlex,STRINGDB
DAG1
Tbio
Family:  Enzyme
Novelty:  0.00149278
p_int:  0.999999289
p_ni:  7.11e-7
Data Source:  BioPlex
PTPRJ
Tbio
Family:  Enzyme
Novelty:  0.00786921
p_int:  0.999996753
p_ni:  0.000003188
p_wrong:  6e-8
Score:  0.552
Data Source:  BioPlex,STRINGDB
LAMA1
Tbio
Novelty:  0.00852401
p_int:  0.999995247
p_ni:  0.000004752
Score:  0.53
Data Source:  BioPlex,STRINGDB
LAMA4
Tbio
Novelty:  0.01288371
p_int:  0.999994866
p_ni:  0.000004862
p_wrong:  2.71e-7
Score:  0.219
Data Source:  BioPlex,STRINGDB
CSPG4
Tbio
Novelty:  0.0038499
p_int:  0.999977861
p_ni:  0.000022139
Score:  0.219
Data Source:  BioPlex,STRINGDB
NID2
Tbio
Novelty:  0.01638372
p_int:  0.999967004
p_ni:  0.000032785
p_wrong:  2.1e-7
Data Source:  BioPlex
CLCN3
Tchem
Family:  IC
Novelty:  0.00416196
p_int:  0.999965819
p_ni:  0.000034181
Score:  0.209
Data Source:  BioPlex,STRINGDB
KIAA1549
Tbio
Novelty:  0.01224835
p_int:  0.999964994
p_ni:  0.000030487
p_wrong:  0.000004518
Score:  0.239
Data Source:  BioPlex,STRINGDB
OSTM1
Tbio
Novelty:  0.03033192
p_int:  0.999961174
p_ni:  0.000027083
p_wrong:  0.000011743
Score:  0.219
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-2 family signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-2 family signaling
Signaling by Interleukins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
galectin 9
VGNC:12400
454519
Macaque
galectin 9
100427967
Mouse
MGI:109496
16859
Rat
RGD:3005
25476
Dog
galectin 9
442861
Species
Name
OMA
EggNOG
Inparanoid
Chimp
galectin 9
Macaque
galectin 9
Mouse
Rat
Dog
galectin 9
Publication Statistics
PubMed Score 287.00
PubMed score by year
PubTator Score 227.37
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title