Protein Summary
Binds galactosides (PubMed:18005988). Has high affinity for the Forssman pentasaccharide (PubMed:18005988). Ligand for HAVCR2/TIM3 (PubMed:16286920). Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death (PubMed:16286920). Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (By similarity). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T-helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity). Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation (PubMed:23817958). Expands regulatory T- ...more
- ENST00000302228
- ENSP00000306228
- ENSG00000168961
- ENST00000313648
- ENSP00000318214
- ENST00000395473
- ENSP00000378856
- HUAT
- LGALS9A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
virus perturbation | 1 | ||
biological term | 0.8 | ||
PubMedID | 0.74 | ||
tissue | 0.6 | ||
gene perturbation | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 287 (req: < 5)
Gene RIFs: 135 (req: <= 3)
Antibodies: 552 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 287 (req: >= 5)
Gene RIFs: 135 (req: > 3)
Antibodies: 552 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 48
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 4
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (4)
Protein-Protein Interactions (125)
PBK
Family: Kinase
Novelty: 0.00278659
p_int: 0.999999447
p_ni: 2e-9
p_wrong: 5.51e-7
Score: 0.219
Data Source: BioPlex,STRINGDB
PTPRJ
Family: Enzyme
Novelty: 0.00786921
p_int: 0.999996753
p_ni: 0.000003188
p_wrong: 6e-8
Score: 0.552
Data Source: BioPlex,STRINGDB
LAMA1
Novelty: 0.00852401
p_int: 0.999995247
p_ni: 0.000004752
Score: 0.53
Data Source: BioPlex,STRINGDB
LAMA4
Novelty: 0.01288371
p_int: 0.999994866
p_ni: 0.000004862
p_wrong: 2.71e-7
Score: 0.219
Data Source: BioPlex,STRINGDB
CSPG4
Novelty: 0.0038499
p_int: 0.999977861
p_ni: 0.000022139
Score: 0.219
Data Source: BioPlex,STRINGDB
NID2
Novelty: 0.01638372
p_int: 0.999967004
p_ni: 0.000032785
p_wrong: 2.1e-7
Data Source: BioPlex
CLCN3
Family: IC
Novelty: 0.00416196
p_int: 0.999965819
p_ni: 0.000034181
Score: 0.209
Data Source: BioPlex,STRINGDB
KIAA1549
Novelty: 0.01224835
p_int: 0.999964994
p_ni: 0.000030487
p_wrong: 0.000004518
Score: 0.239
Data Source: BioPlex,STRINGDB
OSTM1
Novelty: 0.03033192
p_int: 0.999961174
p_ni: 0.000027083
p_wrong: 0.000011743
Score: 0.219
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (5)
Reactome (4)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Reactome | Interleukin-2 family signaling | ||||
Reactome | Signaling by Interleukins | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Immune System | ||||
Interleukin-2 family signaling | ||||
Signaling by Interleukins | ||||
Viral Interactions (0)
Gene Ontology Terms (53)
Functions (4)
Components (5)
Processes (44)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | galectin 9 | VGNC:12400 | 454519 | |||||
Macaque | galectin 9 | 100427967 | ||||||
Mouse | MGI:109496 | 16859 | ||||||
Rat | RGD:3005 | 25476 | ||||||
Dog | galectin 9 | 442861 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | galectin 9 | |||||
Macaque | galectin 9 | |||||
Mouse | ||||||
Rat | ||||||
Dog | galectin 9 | |||||
Publication Statistics
PubMed Score 287.00
PubMed score by year
PubTator Score 227.37
PubTator score by year
Related Publications
Text Mined References (145)
GeneRif Annotations (135)
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