Tchem LGALS8 Galectin-8

Protein Summary

Description

Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PubMed:22246324, PubMed:28077878). Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture (PubMed:22246324, PubMed:28077878). Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed:22246324, PubMed:28077878). Required to restrict infection of bacterial invasion such as S.typhimurium (PubMed:22246324). Also required to restrict infection of Picornaviridae viruses (PubMed:28077878). Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans (PubMed:21288902). This gene encodes a member of the galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O00214
• O15215
• Q5T3P5
• Q5T3Q4
• Q8TEV1
• Q96B92
• Q9BXC8
• Q9H584
• Q9H585
• Q9UEZ6
• Q9UP32
• Q9UP33
• Q9UP34
• Gal-8

Gene Name

• LGALS8

Ensembl ID

• ENST00000341872
• ENSP00000342139
• ENSG00000116977
• ENST00000352231
• ENSP00000309576
• ENST00000366584
• ENSP00000355543
• ENST00000450372
• ENSP00000408657
• ENST00000526589
• ENSP00000435460
• ENST00000526634
• ENSP00000437040
• ENST00000527974
• ENSP00000431398

Symbol

• Gal-8
• PCTA1
• PCTA-1
• Po66-CBP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
virus perturbation	0.99
disease perturbation	0.96
tissue sample	0.79
cell type or tissue	0.77

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Galectin-8

Protein / Cell Adhesion Molecule / Galectin-8

DTO Classes

Protein / Signaling / Galectin-8

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.8   (req: < 5)

Gene RIFs: 69   (req: <= 3)

Antibodies: 369   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.8   (req: >= 5)

Gene RIFs: 69   (req: > 3)

Antibodies: 369   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0