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Tbio
LGALS3BP
Galectin-3-binding protein

Protein Summary
Description
Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells. The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (HIV). It appears to be implicated in immune response associated with natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity. Using fluorescence in situ hybridization the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds galectin 1. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262776
  • ENSP00000262776
  • ENSG00000108679

Symbol
  • M2BP
  • 90K
  • M2BP
  • gp90
  • CyCAP
  • BTBD17B
  • MAC-2-BP
  • TANGO10B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
interacting protein
0.99
gene perturbation
0.96
disease perturbation
0.93
small molecule perturbation
0.85


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 463.91   (req: < 5)
Gene RIFs: 66   (req: <= 3)
Antibodies: 359   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 463.91   (req: >= 5)
Gene RIFs: 66   (req: > 3)
Antibodies: 359   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (102)
SPRYD3
Tdark
Novelty:  3.99875244
p_int:  0.999999749
p_ni:  2.35e-7
p_wrong:  1.5e-8
Score:  0.189
Data Source:  BioPlex,STRINGDB
HECTD4
Tbio
Family:  Enzyme
Novelty:  0.10275533
p_int:  0.999998284
p_ni:  0.000001706
p_wrong:  1e-8
Score:  0.19
Data Source:  BioPlex,STRINGDB
DNAJC13
Tbio
Novelty:  0.03251995
p_int:  0.999996711
p_ni:  0.000003289
Data Source:  BioPlex
HELZ2
Tdark
Family:  Enzyme
Novelty:  0.1810765
p_int:  0.999981258
p_ni:  0.000018724
p_wrong:  1.8e-8
Score:  0.278
Data Source:  BioPlex,STRINGDB
MZT2A
Tdark
Novelty:  1.66535264
p_int:  0.999969925
p_ni:  0.000002469
p_wrong:  0.000027606
Score:  0.597
Data Source:  BioPlex,STRINGDB
MYCBP2
Tbio
Family:  Enzyme
Novelty:  0.00413684
p_int:  0.999952839
p_ni:  0.000047158
p_wrong:  3e-9
Data Source:  BioPlex
GNE
Tbio
Family:  Enzyme
Novelty:  0.00285751
p_int:  0.999951299
p_ni:  5.65e-7
p_wrong:  0.000048136
Score:  0.181
Data Source:  BioPlex,STRINGDB
TWNK
Tbio
Novelty:  0.00393371
p_int:  0.99994902
p_ni:  0.00005098
Data Source:  BioPlex
TUBGCP4
Tbio
Novelty:  0.04549455
p_int:  0.999801541
p_ni:  0.000198459
Score:  0.188
Data Source:  BioPlex,STRINGDB
FBXO45
Tbio
Novelty:  0.05784607
p_int:  0.999324257
p_ni:  0.000483686
p_wrong:  0.000192058
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
65.3
gut microbiome measurement
1
1
3
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
65.3
gut microbiome measurement
3
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
galectin 3 binding protein
VGNC:10147
454930
Macaque
galectin 3 binding protein
710853
Mouse
MGI:99554
19039
Rat
RGD:620837
245955
Dog
galectin 3 binding protein [Source:HGNC Symbol;Acc:HGNC:6564]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
galectin 3 binding protein
Macaque
galectin 3 binding protein
Mouse
Rat
Dog
galectin 3 binding protein [Source:HGNC Symbol;Acc:HGNC:6564]
Publication Statistics
PubMed Score 463.91
PubMed score by year
PubTator Score 241.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title