Tbio LGALS2 Galectin-2

Protein Summary

Description

This protein binds beta-galactoside. Its physiological function is not yet known. The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P05162
• Q6FGY4
• Gal-2

Gene Name

• LGALS2

Ensembl ID

• ENST00000215886
• ENSP00000215886
• ENSG00000100079

Symbol

• HL14

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.73
PubMedID	0.7
biological term	0.46
tissue sample	0.45
disease	0.43

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Galectin-2

Protein / Cell Adhesion Molecule / Galectin-2

DTO Classes

Protein / Signaling / Galectin-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.74   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 269   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.74   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0