Tbio LGALS14 Placental protein 13-like

Protein Summary

Description

Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis. This gene is predominantly expressed in placenta. The encoded protein belongs to the galectin (galaptin/S-lectin) family. The members of galectin family contain one or two carbohydrate recognition domains, which can bind beta-galactoside. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8TCE9
• A8MPV8
• B2R530
• C5HZ19
• Q7Z4X8
• Q96KD4
• Q96KD5
• Q96KD6
• Q9NR03

Gene Name

• LGALS14

Ensembl ID

• ENST00000360675
• ENSP00000353893
• ENSG00000006659
• ENST00000392052
• ENSP00000375905

Symbol

• PPL13
• CLC2
• PPL13

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.58
cell line	0.52
tissue	0.5
tissue sample	0.41
phenotype	0.36

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Placental Protein 13-like

Protein / Cell Adhesion Molecule / Placental Protein 13-like

DTO Classes

Protein / Signaling / Placental Protein 13-like

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.68   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 58   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.68   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0