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Tchem
LGALS1
Galectin-1

Protein Summary
Description
Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215909
  • ENSP00000215909
  • ENSG00000100097

Symbol
  • GBP
  • GAL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
interacting protein
0.98
transcription factor perturbation
0.98
PubMedID
0.96
disease perturbation
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 985.22   (req: < 5)
Gene RIFs: 310   (req: <= 3)
Antibodies: 842   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 985.22   (req: >= 5)
Gene RIFs: 310   (req: > 3)
Antibodies: 842   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (226)
LRFN4
Tbio
Novelty:  0.12511571
p_int:  0.999806548
p_ni:  0.000193452
Data Source:  BioPlex
ALCAM
Tbio
Novelty:  0.00244371
p_int:  0.999666664
p_ni:  0.000333316
p_wrong:  2e-8
Score:  0.369
Data Source:  BioPlex,STRINGDB
SEMA4C
Tbio
Novelty:  0.01237067
p_int:  0.999386782
p_ni:  0.000613218
Data Source:  BioPlex
LINGO2
Tbio
Novelty:  0.06112205
p_int:  0.992450928
p_ni:  0.007549009
p_wrong:  6.3e-8
Data Source:  BioPlex
CD68
Tbio
Novelty:  0.00017859
p_int:  0.988327051
p_ni:  0.011672602
p_wrong:  3.47e-7
Score:  0.237
Data Source:  BioPlex,STRINGDB
PECAM1
Tbio
Novelty:  0.00013373
p_int:  0.987617048
p_ni:  0.012382788
p_wrong:  1.64e-7
Score:  0.379
Data Source:  BioPlex,STRINGDB
FAM24B
Tdark
Novelty:  1.04675689
p_int:  0.977558999
p_ni:  0.022389325
p_wrong:  0.000051676
Data Source:  BioPlex
CDHR5
Tbio
Novelty:  0.08525208
p_int:  0.976479912
p_ni:  0.023519826
p_wrong:  2.62e-7
Data Source:  BioPlex
S1PR2
Tchem
Family:  GPCR
Novelty:  0.00372765
p_int:  0.976311571
p_ni:  0.023688309
p_wrong:  1.2e-7
Data Source:  BioPlex
NTRK3
Tclin
Family:  Kinase
Novelty:  0.00177321
p_int:  0.976227229
p_ni:  0.023772515
p_wrong:  2.56e-7
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of proteins (R-HSA-392499)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Reactome
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
2
2
2
58.9
age-related hearing impairment
2
1
1
1.1
52.7
serum albumin measurement
1
1
1
50.6
pulse pressure measurement
1
1
1
46.9
cognitive function measurement
3
1
3
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
2
58.9
age-related hearing impairment
1
1.1
52.7
serum albumin measurement
1
50.6
pulse pressure measurement
1
46.9
cognitive function measurement
3
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
galectin 1
VGNC:10089
742148
Macaque
galectin 1
700896
Mouse
MGI:96777
16852
Rat
RGD:69355
56646
Dog
galectin 1
610276
Species
Name
OMA
EggNOG
Inparanoid
Chimp
galectin 1
Macaque
galectin 1
Mouse
Rat
Dog
galectin 1
Publication Statistics
PubMed Score 985.22
PubMed score by year
PubTator Score 1672.98
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title