Tchem LGALS1 Galectin-1

Protein Summary

Description

Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. This gene product may act as an autocrine negative growth factor that regulates cell proliferation. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P09382
• B2R5E8
• Q9UDK5
• Gal-1

Gene Name

• LGALS1

Ensembl ID

• ENST00000215909
• ENSP00000215909
• ENSG00000100097

Symbol

• GBP
• GAL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
interacting protein	0.98
transcription factor perturbation	0.98
PubMedID	0.96
disease perturbation	0.93

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Galectin-1

Protein / Cell Adhesion Molecule / Galectin-1

DTO Classes

Protein / Signaling / Galectin-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1203.84   (req: < 5)

Gene RIFs: 394   (req: <= 3)

Antibodies: 842   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1203.84   (req: >= 5)

Gene RIFs: 394   (req: > 3)

Antibodies: 842   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0