Tbio LFNG Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe

Protein Summary

Description

Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (By similarity). Decreases the binding of JAG1 to NOTCH2 but not that of DLL1 (PubMed:11346656). Essential mediator of somite segmentation and patterning (By similarity). This gene is a member of the glycosyltransferase 31 gene family. Members of this gene family, which also includes the MFNG (GeneID: 4242) and RFNG (GeneID: 5986) genes, encode evolutionarily conserved glycosyltransferases that act in the Notch signaling pathway to define boundaries during embryonic development. While their genomic structure is distinct from other glycosyltransferases, these proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. The protein encoded by this gene is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150). Mutations in this gene have been associated with autosomal recessive spondylocostal dysostosis 3. [provided by RefSeq, May 2018]

Uniprot Accession IDs

• Q8NES3
• B3KTY6
• B5MCR5
• O00589
• Q96C39
• Q9UJW5

Gene Name

• LFNG

Ensembl ID

• ENST00000222725
• ENSP00000222725
• ENSG00000106003
• ENST00000338732
• ENSP00000343095
• ENST00000359574
• ENSP00000352579
• ENST00000402045
• ENSP00000384786
• ENST00000402506
• ENSP00000385764

Symbol

• SCDO3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.93
gene perturbation	0.92
transcription factor	0.86
transcription factor perturbation	0.68
cellular component	0.63

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / Beta-1,3-n-acetylglucosaminyltransferase Lunatic Fringe

Protein / Signaling Molecule / Beta-1,3-n-acetylglucosaminyltransferase Lunatic Fringe

DTO Classes

Protein / Enzyme / Transferase / Glycosyltransferase / Beta-1,3-n-acetylglucosaminyltransferase Lunatic Fringe

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 301   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 301   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0