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Tbio
LETMD1
LETM1 domain-containing protein 1

Protein Summary
Description
Involved in tumorigenesis and may function as a negative regulator of the p53/TP53. This gene encodes a mitochondrial outer membrane protein. It has a potential role in tumorigenesis, which may result from negative regulation of the p53 tumor suppressor gene. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262055
  • ENSP00000262055
  • ENSG00000050426
  • ENST00000418425
  • ENSP00000389903
  • ENST00000550100
  • ENSP00000447047
  • ENST00000550929
  • ENSP00000450163

Symbol
  • HCCR
  • HCCR1
  • HCCR2
  • HCCR-1
  • HCCR-2
  • HCRR-2
  • SLC55A3
  • 1110019O13Rik
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
histone modification site profile
0.93
transcription factor binding site profile
0.91
transcription factor perturbation
0.84
PubMedID
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.4   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.4   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0