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Tbio
LETM1
Mitochondrial proton/calcium exchanger protein

Protein Summary
Description
Mitochondrial proton/calcium antiporter that mediates proton-dependent calcium efflux from mitochondrion (PubMed:19797662). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (PubMed:18628306). Required for the maintenance of the tubular shape and cristae organization (PubMed:18628306). In contrast to SLC8B1/NCLX, does not constitute the major factor for mitochondrial calcium extrusion (PubMed:24898248). This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302787
  • ENSP00000305653
  • ENSG00000168924

Symbol
  • SLC55A1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.88
kinase perturbation
0.81
histone modification site profile
0.79
cellular component
0.72
transcription factor binding site profile
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.82   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 237   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 78.82   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 237   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (73)
FSD2
Tbio
Novelty:  0.1302271
p_int:  0.999858353
p_ni:  0.000141641
p_wrong:  6e-9
Data Source:  BioPlex
USP47
Tchem
Family:  Enzyme
Novelty:  0.07579226
p_int:  0.998576265
p_ni:  0.001423735
Score:  0.155
Data Source:  BioPlex,STRINGDB
SNRNP27
Tbio
Novelty:  0.0175187
p_int:  0.998519338
p_ni:  0.001480658
p_wrong:  4e-9
Data Source:  BioPlex
RCL1
Tbio
Family:  Enzyme
Novelty:  0.02116964
p_int:  0.997877174
p_ni:  0.002122826
Data Source:  BioPlex
CYP1A1
Tchem
Novelty:  0.0002404
p_int:  0.996508533
p_ni:  0.003491447
p_wrong:  2e-8
Score:  0.179
Data Source:  BioPlex,STRINGDB
PCDHGB4
Tdark
Novelty:  0.25018904
p_int:  0.996207525
p_ni:  0.003792474
p_wrong:  1e-9
Data Source:  BioPlex
OR2T10
Tdark
Family:  oGPCR
Novelty:  5.20023909
p_int:  0.972568374
p_ni:  0.027391505
p_wrong:  0.000040121
Data Source:  BioPlex
CARTPT
Tbio
Novelty:  0.00224864
p_int:  0.972417824
p_ni:  0.02758217
p_wrong:  6e-9
Data Source:  BioPlex
RABIF
Tbio
Novelty:  0.22512579
p_int:  0.969599917
p_ni:  0.030366035
p_wrong:  0.000034048
Data Source:  BioPlex
HSD3B2
Tclin
Family:  Enzyme
Novelty:  0.00711552
p_int:  0.963164664
p_ni:  0.025686344
p_wrong:  0.011148992
Score:  0.183
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Mitochondrial calcium ion transport (R-HSA-8949215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial calcium ion transport
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Mitochondrial calcium ion transport
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
3
3
1.1
88.6
BMI-adjusted hip circumference
2
4
4
81.9
4
2
0
1.2
79.3
mean reticulocyte volume
1
1
1
63.7
1
1
0
1.1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
88.6
BMI-adjusted hip circumference
4
81.9
0
1.2
79.3
mean reticulocyte volume
1
63.7
0
1.1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine zipper and EF-hand containing transmembrane protein 1
VGNC:8266
461068
Macaque
leucine zipper and EF-hand containing transmembrane protein 1
722530
Mouse
MGI:1932557
56384
Rat
RGD:1359678
305457
Dog
leucine zipper and EF-hand containing transmembrane protein 1
VGNC:42641
488807
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine zipper and EF-hand containing transmembrane protein 1
Macaque
leucine zipper and EF-hand containing transmembrane protein 1
Mouse
Rat
Dog
leucine zipper and EF-hand containing transmembrane protein 1
Publication Statistics
PubMed Score 78.82
PubMed score by year
PubTator Score 40.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title