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Tclin
LEPR
Leptin receptor

Protein Summary
Description
Receptor for hormone LEP/leptin (Probable) (PubMed:22405007). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (By similarity) (PubMed:9537324). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:25060689, PubMed:12504075, PubMed:8805376). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344610
  • ENSP00000340884
  • ENSG00000116678
  • ENST00000349533
  • ENSP00000330393
  • ENST00000371058
  • ENSP00000360097
  • ENST00000371059
  • ENSP00000360098
  • ENST00000371060
  • ENSP00000360099
  • ENST00000616738
  • ENSP00000483390

Symbol
  • DB
  • OBR
  • OBR
  • OB-R
  • CD295
  • LEP-R
  • LEPRD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.93
protein domain
0.92
trait
0.75
transcription factor binding site profile
0.75
PubMedID
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1091.02   (req: < 5)
Gene RIFs: 471   (req: <= 3)
Antibodies: 834   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1091.02   (req: >= 5)
Gene RIFs: 471   (req: > 3)
Antibodies: 834   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1