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Tbio
LEP
Leptin

Protein Summary
Description
Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (PubMed:17344214, PubMed:15899045, PubMed:19688109). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity (By similarity) (PubMed:8589726, PubMed:11460888, PubMed:19688109, PubMed:24340098, PubMed:25060689). In the arcuate nucleus of the hypothalamus, activates by depolarization POMC ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308868
  • ENSP00000312652
  • ENSG00000174697

Symbol
  • OB
  • OBS
  • OB
  • OBS
  • LEPD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
gene perturbation
0.98
disease
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21116.6   (req: < 5)
Gene RIFs: 1453   (req: <= 3)
Antibodies: 1365   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21116.6   (req: >= 5)
Gene RIFs: 1453   (req: > 3)
Antibodies: 1365   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 93
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (533)
LEPR
Tclin
Novelty:  0.00070587
p_int:  0.99999993
p_ni:  7e-8
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
GLB1L
Tdark
Family:  Enzyme
Novelty:  0.43027328
p_int:  0.996501188
p_ni:  0.001306635
p_wrong:  0.002192178
Data Source:  BioPlex
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.852172792
p_ni:  0.147827208
Score:  0.617
Data Source:  BioPlex,STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.992
Data Source:  Reactome,STRINGDB
PPARG
Tclin
Family:  NR
Novelty:  0.00010033
Score:  0.991
Data Source:  STRINGDB
SOCS3
Tbio
Novelty:  0.00106095
Score:  0.989
Data Source:  Reactome,STRINGDB
GCG
Tchem
Novelty:  0.00004879
Score:  0.989
Data Source:  STRINGDB
JAK2
Tclin
Family:  Kinase
Novelty:  0.00022894
Score:  0.984
Data Source:  Reactome,STRINGDB
IRS1
Tchem
Novelty:  0.00048281
Score:  0.982
Data Source:  Reactome,STRINGDB
CRP
Tbio
Novelty:  0.00001517
Score:  0.981
Data Source:  STRINGDB
Nearest Tclin Targets (17)
Explore Nearest Tclin Targets
Pathways (70)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Incretin synthesis, secretion, and inactivation
Reactome
Metabolism of proteins
Reactome
Peptide hormone metabolism
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Developmental Biology
Incretin synthesis, secretion, and inactivation
Metabolism of proteins
Peptide hormone metabolism
Signal Transduction
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted leptin measurement
10
3
13
87.7
leptin measurement
7
3
8
70.2
2
1
0
1.1
12.8
high density lipoprotein cholesterol measurement
1
1
1
11.5
comparative body size at age 10, self-reported
1
1
1
10.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted leptin measurement
13
87.7
leptin measurement
8
70.2
0
1.1
12.8
high density lipoprotein cholesterol measurement
1
11.5
comparative body size at age 10, self-reported
1
10.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
leptin
698728
Mouse
MGI:104663
16846
Rat
RGD:3000
25608
Dog
leptin
VGNC:42637
403616
Horse
leptin
100034042
Species
Name
OMA
EggNOG
Inparanoid
Macaque
leptin
Mouse
Rat
Dog
leptin
Horse
leptin
Publication Statistics
PubMed Score 21116.60
PubMed score by year
PubTator Score 6553.87
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title