LEMD3
Inner nuclear membrane protein Man1
Protein Summary
Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.[provided by RefSeq, Nov 2009]
- ENST00000308330
- ENSP00000308369
- ENSG00000174106
- MAN1
- MAN1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.76 | ||
interacting protein | 0.75 | ||
microRNA | 0.75 | ||
cellular component | 0.7 | ||
kinase perturbation | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 217.67 (req: < 5)
Gene RIFs: 21 (req: <= 3)
Antibodies: 127 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 217.67 (req: >= 5)
Gene RIFs: 21 (req: > 3)
Antibodies: 127 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (114)
SMAD2
Family: TF
Novelty: 0.00040166
p_int: 0.999925484
p_ni: 0.000074515
Score: 0.792
Data Source: BioPlex,STRINGDB
SMAD3
Family: TF
Novelty: 0.00048058
p_int: 0.999538185
p_ni: 0.000461815
Score: 0.819
Data Source: BioPlex,STRINGDB
OPALIN
Novelty: 0.08221612
p_int: 0.999438936
p_ni: 0.000561063
p_wrong: 1e-9
Data Source: BioPlex
FURIN
Family: Enzyme
Novelty: 0.00055079
p_int: 0.999418037
p_ni: 0.000581961
p_wrong: 2e-9
Data Source: BioPlex
SMAD9
Family: TF
Novelty: 0.00285887
p_int: 0.999266515
p_ni: 0.000733485
Score: 0.707
Data Source: BioPlex,STRINGDB
AOC2
Family: Enzyme
Novelty: 0.0048282
p_int: 0.997592199
p_ni: 0.002407801
Score: 0.187
Data Source: BioPlex,STRINGDB
CTLA4
Novelty: 0.00012781
p_int: 0.995038637
p_ni: 0.004961359
p_wrong: 3e-9
Data Source: BioPlex
MME
Family: Enzyme
Novelty: 0.00019144
p_int: 0.994968151
p_ni: 0.005031849
Data Source: BioPlex
Nearest Tclin Targets
Pathways (22)
Reactome (10)
WikiPathways (12)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Depolymerisation of the Nuclear Lamina | ||||
Reactome | Initiation of Nuclear Envelope Reformation | ||||
Reactome | M Phase | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Depolymerisation of the Nuclear Lamina | ||||
Initiation of Nuclear Envelope Reformation | ||||
M Phase | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (1)
Components (5)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
hippocampal CA1 volume | 2 | 1 | 0 | 14 | 91.7 | ||||
snoring measurement | 4 | 1 | 3 | 1 | 87.3 | ||||
brain volume measurement | 26 | 1 | 26 | 85.6 | |||||
granule cell layer dentate gyrus volume | 1 | 1 | 0 | 8.8 | 85 | ||||
hippocampal CA3 volume | 1 | 1 | 0 | 7.8 | 84.7 | ||||
Items per page:
1 – 5 of 14
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
hippocampal CA1 volume | 0 | 14 | 91.7 | ||||
snoring measurement | 3 | 1 | 87.3 | ||||
brain volume measurement | 26 | 85.6 | |||||
granule cell layer dentate gyrus volume | 0 | 8.8 | 85 | ||||
hippocampal CA3 volume | 0 | 7.8 | 84.7 | ||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | LEM domain containing 3 | VGNC:5450 | 452050 | |||||
Macaque | LEM domain containing 3 | 717597 | ||||||
Mouse | MGI:3580376 | 380664 | ||||||
Rat | RGD:1596822 | 680066 | ||||||
Dog | LEM domain containing 3 | VGNC:42633 | 608380 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | LEM domain containing 3 | |||||
Macaque | LEM domain containing 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | LEM domain containing 3 | |||||
Publication Statistics
PubMed Score 217.67
PubMed score by year
PubTator Score 106.22
PubTator score by year
Related Publications
Text Mined References (27)
GeneRif Annotations (21)
Items per page:
0 of 0
PMID | Year | Title |
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