LEMD3
Inner nuclear membrane protein Man1
Protein Summary
Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.[provided by RefSeq, Nov 2009]
- ENST00000308330
- ENSP00000308369
- ENSG00000174106
- MAN1
- MAN1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.76 | ||
interacting protein | 0.75 | ||
microRNA | 0.75 | ||
cellular component | 0.7 | ||
kinase perturbation | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 179.08 (req: < 5)
Gene RIFs: 21 (req: <= 3)
Antibodies: 127 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 179.08 (req: >= 5)
Gene RIFs: 21 (req: > 3)
Antibodies: 127 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (114)
SMAD2
Family: TF
Novelty: 0.00040166
p_int: 0.999925484
p_ni: 0.000074515
Score: 0.792
Data Source: BioPlex,STRINGDB
SMAD3
Family: TF
Novelty: 0.00048058
p_int: 0.999538185
p_ni: 0.000461815
Score: 0.819
Data Source: BioPlex,STRINGDB
OPALIN
Novelty: 0.08221612
p_int: 0.999438936
p_ni: 0.000561063
p_wrong: 1e-9
Data Source: BioPlex
FURIN
Family: Enzyme
Novelty: 0.00055079
p_int: 0.999418037
p_ni: 0.000581961
p_wrong: 2e-9
Data Source: BioPlex
SMAD9
Family: TF
Novelty: 0.00285887
p_int: 0.999266515
p_ni: 0.000733485
Score: 0.707
Data Source: BioPlex,STRINGDB
AOC2
Family: Enzyme
Novelty: 0.0048282
p_int: 0.997592199
p_ni: 0.002407801
Score: 0.187
Data Source: BioPlex,STRINGDB
CTLA4
Novelty: 0.00012781
p_int: 0.995038637
p_ni: 0.004961359
p_wrong: 3e-9
Data Source: BioPlex
MME
Family: Enzyme
Novelty: 0.00019144
p_int: 0.994968151
p_ni: 0.005031849
Data Source: BioPlex
Nearest Tclin Targets
Pathways (22)
Reactome (10)
WikiPathways (12)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Depolymerisation of the Nuclear Lamina | ||||
Reactome | Initiation of Nuclear Envelope Reformation | ||||
Reactome | M Phase | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Depolymerisation of the Nuclear Lamina | ||||
Initiation of Nuclear Envelope Reformation | ||||
M Phase | ||||
Viral Interactions (0)
Gene Ontology Terms (12)
Functions (1)
Components (5)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
hippocampal CA1 volume | 2 | 1 | 0 | 14 | 78.5 | ||||
granule cell layer dentate gyrus volume | 1 | 1 | 0 | 8.8 | 73.5 | ||||
hippocampal CA4 volume | 1 | 1 | 0 | 7.3 | 71.5 | ||||
hippocampal CA3 volume | 1 | 1 | 0 | 7.8 | 70.8 | ||||
presubiculum volume | 1 | 1 | 0 | 5.6 | 64.4 | ||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
hippocampal CA1 volume | 0 | 14 | 78.5 | ||||
granule cell layer dentate gyrus volume | 0 | 8.8 | 73.5 | ||||
hippocampal CA4 volume | 0 | 7.3 | 71.5 | ||||
hippocampal CA3 volume | 0 | 7.8 | 70.8 | ||||
presubiculum volume | 0 | 5.6 | 64.4 | ||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | LEM domain containing 3 | VGNC:5450 | 452050 | |||||
Macaque | LEM domain containing 3 | 717597 | ||||||
Mouse | MGI:3580376 | 380664 | ||||||
Rat | RGD:1596822 | 680066 | ||||||
Dog | LEM domain containing 3 | VGNC:42633 | 608380 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | LEM domain containing 3 | |||||
Macaque | LEM domain containing 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | LEM domain containing 3 | |||||
Publication Statistics
PubMed Score 179.08
PubMed score by year
PubTator Score 106.22
PubTator score by year
Related Publications
Text Mined References (27)
GeneRif Annotations (21)
Items per page:
0 of 0
PMID | Year | Title |
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