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Tbio
LEMD2
LEM domain-containing protein 2

Protein Summary
Description
Involved in nuclear structure organization (PubMed:16339967). Required for maintaining the integrity of the nuclear envelope (PubMed:17097643). Required for embryonic development and is involved in regulation of several signaling pathways such as MAPK and AKT. Required for myoblast differentiation involving regulation of ERK signaling (By similarity). This gene encodes a LEM domain-containing transmembrane protein of the inner nuclear membrane. The protein is involved in nuclear structure organization and plays a role in cell signaling and differentiation. Mutations in this gene result in Cataract 46, juvenile-onset. Multiple transcript variants have been found for this gene. [provided by RefSeq, Feb 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293760
  • ENSP00000293760
  • ENSG00000161904
  • ENST00000508327
  • ENSP00000421704
  • ENST00000614475
  • ENSP00000478539

Symbol
  • LEM2
  • NET25
  • CTRCT42
  • dJ482C21.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.84
virus perturbation
0.76
cellular component
0.74
kinase perturbation
0.71
cell type or tissue
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.52   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.52   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (73)
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.999923134
p_ni:  0.000076866
Data Source:  BioPlex
GDPD5
Tbio
Family:  Enzyme
Novelty:  0.05871733
p_int:  0.998949407
p_ni:  0.001050592
p_wrong:  1e-9
Data Source:  BioPlex
ASPH
Tchem
Family:  Enzyme
Novelty:  0.00291455
p_int:  0.992294941
p_ni:  0.007705059
Data Source:  BioPlex
CHRNA9
Tchem
Family:  IC
Novelty:  0.05009815
p_int:  0.992066701
p_ni:  0.007933298
Data Source:  BioPlex
CHRNA3
Tclin
Family:  IC
Novelty:  0.00659767
p_int:  0.990450314
p_ni:  0.009549686
Data Source:  BioPlex
SLC39A4
Tbio
Family:  Transporter
Novelty:  0.00742159
p_int:  0.990043167
p_ni:  0.009956833
Data Source:  BioPlex
UPK1A
Tbio
Novelty:  0.01748122
p_int:  0.989957291
p_ni:  0.010042709
Data Source:  BioPlex
SLC7A1
Tbio
Family:  Transporter
Novelty:  0.00197313
p_int:  0.988507166
p_ni:  0.011492834
Data Source:  BioPlex
SLC39A8
Tbio
Family:  Transporter
Novelty:  0.00923197
p_int:  0.986237102
p_ni:  0.013762898
Data Source:  BioPlex
CHRNB3
Tchem
Family:  IC
Novelty:  0.031456
p_int:  0.979008265
p_ni:  0.020991735
Score:  0.224
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Depolymerisation of the Nuclear Lamina
Reactome
Initiation of Nuclear Envelope Reformation
Reactome
M Phase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Depolymerisation of the Nuclear Lamina
Initiation of Nuclear Envelope Reformation
M Phase
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (36)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
phosphorus measurement
2
2
2
88.9
self reported educational attainment
3
3
3
78.8
platelet crit
2
2
2
78.8
schizophrenia
3
2
1
1.1
76.6
allergic disease
1
1
0
1
67.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
phosphorus measurement
2
88.9
self reported educational attainment
3
78.8
platelet crit
2
78.8
schizophrenia
1
1.1
76.6
allergic disease
0
1
67.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LEM domain containing 2
VGNC:3368
462621
Macaque
LEM domain containing 2
718463
Mouse
MGI:2385045
224640
Dog
LEM domain containing 2
VGNC:42632
607981
Cow
LEM domain containing 2
VGNC:30836
518023
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LEM domain containing 2
Macaque
LEM domain containing 2
Mouse
Dog
LEM domain containing 2
Cow
LEM domain containing 2
Publication Statistics
PubMed Score 10.52
PubMed score by year
PubTator Score 9.29
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title