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Tbio
LEFTY1
Left-right determination factor 1

Protein Summary
Description
Required for left-right axis determination as a regulator of LEFTY2 and NODAL. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. This gene is closely linked to both a related family member and a related pseudogene. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272134
  • ENSP00000272134
  • ENSG00000243709

Symbol
  • LEFTB
  • LEFTYB
  • LEFTB
  • LEFTYB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
biological process
0.71
PubMedID
0.7
kinase perturbation
0.6
phenotype
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.26   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 328   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.26   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 328   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (82)
LEFTY2
Tbio
Novelty:  0.01038653
p_int:  0.999999998
p_wrong:  2e-9
Score:  0.972
Data Source:  BioPlex,STRINGDB
MTOR
Tclin
Family:  Kinase
Novelty:  0.00012333
p_int:  0.995019087
p_ni:  0.004980913
Score:  0.208
Data Source:  BioPlex,STRINGDB
TDGF1
Tbio
Novelty:  0.00527099
Score:  0.981
Data Source:  Reactome,STRINGDB
ACVR2B
Tchem
Family:  Kinase
Novelty:  0.00555742
Score:  0.978
Data Source:  Reactome,STRINGDB
NODAL
Tbio
Novelty:  0.01033642
Score:  0.973
Data Source:  Reactome,STRINGDB
ACVR1B
Tchem
Family:  Kinase
Novelty:  0.00633595
Score:  0.966
Data Source:  Reactome,STRINGDB
CFC1
Tbio
Novelty:  0.01787772
Score:  0.966
Data Source:  Reactome,STRINGDB
ACVR1C
Tbio
Family:  Kinase
Novelty:  0.01675672
Score:  0.948
Data Source:  Reactome,STRINGDB
ACVR2A
Tchem
Family:  Kinase
Novelty:  0.0063932
Score:  0.942
Data Source:  Reactome,STRINGDB
TGFB3
Tbio
Novelty:  0.00068568
Score:  0.815
Data Source:  STRINGDB
Pathways (11)
Developmental Biology (R-HSA-1266738)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Regulation of signaling by NODAL
Reactome
Signaling by NODAL
Name
Explore in Pharos
Explore in Source
Developmental Biology
Regulation of signaling by NODAL
Signaling by NODAL
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
56.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
56.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Cow
left-right determination factor 2-like
100336971
Opossum
left-right determination factor 2
100025872
Chicken
left-right determination factor 2
CGNC:49363
395529
Anole lizard
left-right determination factor 2-like
100555191
Zebrafish
ZDB-GENE-990630-11
30146
Species
Name
OMA
EggNOG
Inparanoid
Cow
left-right determination factor 2-like
Opossum
left-right determination factor 2
Chicken
left-right determination factor 2
Anole lizard
left-right determination factor 2-like
Zebrafish
Publication Statistics
PubMed Score 56.26
PubMed score by year
PubTator Score 16.86
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title