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Tchem
LEF1
Lymphoid enhancer-binding factor 1

Protein Summary
Description
Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells. This gene encodes a transcription factor belonging to a family of pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265165
  • ENSP00000265165
  • ENSG00000138795
  • ENST00000379951
  • ENSP00000369284
  • ENST00000438313
  • ENSP00000406176
  • ENST00000506680
  • ENSP00000422334
  • ENST00000510624
  • ENSP00000422840

Symbol
  • LEF-1
  • TCF10
  • TCF7L3
  • TCF1ALPHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
PubMedID
0.98
hub protein
0.85
transcription factor
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 552.85   (req: < 5)
Gene RIFs: 126   (req: <= 3)
Antibodies: 722   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 552.85   (req: >= 5)
Gene RIFs: 126   (req: > 3)
Antibodies: 722   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 89
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (312)
PRMT6
Tchem
Family:  Epigenetic
Novelty:  0.01734208
p_int:  0.901663692
p_ni:  0.0983363
p_wrong:  7e-9
Score:  0.288
Data Source:  BioPlex,STRINGDB
CTNNB1
Tchem
Novelty:  0.0000744
Score:  0.999
Data Source:  Reactome,STRINGDB
AXIN2
Tchem
Novelty:  0.00273189
Score:  0.988
Data Source:  STRINGDB
NLK
Tchem
Family:  Kinase
Novelty:  0.01512201
Score:  0.986
Data Source:  Reactome,STRINGDB
PITX2
Tbio
Family:  TF
Novelty:  0.00216568
Score:  0.982
Data Source:  STRINGDB
MYC
Tchem
Family:  TF
Novelty:  0.00005734
Score:  0.981
Data Source:  STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.978
Data Source:  Reactome,STRINGDB
TLE1
Tbio
Novelty:  0.00594261
Score:  0.975
Data Source:  Reactome,STRINGDB
CCND1
Tchem
Novelty:  0.0001186
Score:  0.969
Data Source:  STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
Score:  0.968
Data Source:  Reactome,STRINGDB
Pathways (83)
Beta-catenin independent WNT signaling (R-HSA-3858494)

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Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Beta-catenin independent WNT signaling
Reactome
Binding of TCF/LEF:CTNNB1 to target gene promoters
Reactome
Ca2+ pathway
Reactome
Deactivation of the beta-catenin transactivating complex
Reactome
Degradation of beta-catenin by the destruction complex
Name
Explore in Pharos
Explore in Source
Beta-catenin independent WNT signaling
Binding of TCF/LEF:CTNNB1 to target gene promoters
Ca2+ pathway
Deactivation of the beta-catenin transactivating complex
Degradation of beta-catenin by the destruction complex
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (95)
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Items per page:
10
1 – 10 of 22
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
1
2
0
1.2
75.7
testosterone measurement
2
1
2
71.9
2
2
0
1.2
53.1
1
1
0
1.1
49.5
heel bone mineral density
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.2
75.7
testosterone measurement
2
71.9
0
1.2
53.1
0
1.1
49.5
heel bone mineral density
1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lymphoid enhancer binding factor 1
VGNC:6477
461425
Macaque
lymphoid enhancer binding factor 1
695776
Mouse
MGI:96770
16842
Rat
RGD:620241
161452
Dog
lymphoid enhancer binding factor 1
VGNC:42630
478507
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lymphoid enhancer binding factor 1
Macaque
lymphoid enhancer binding factor 1
Mouse
Rat
Dog
lymphoid enhancer binding factor 1
Publication Statistics
PubMed Score 552.85
PubMed score by year
PubTator Score 365.50
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title