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Tbio
LEAP2
Liver-expressed antimicrobial peptide 2

Protein Summary
Description
Has an antimicrobial activity. This gene encodes a cysteine-rich cationic antimicrobial peptide that is expressed predominantly in the liver. The mature peptide has activity against gram-positive bacteria and yeasts. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296877
  • ENSP00000296877
  • ENSG00000164406

Symbol
  • LEAP-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
cell type or tissue
0.8
tissue sample
0.6
gene perturbation
0.57
chemical
0.41


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.88   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 32   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.88   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (17)
PACS1
Tbio
Novelty:  0.02030091
p_int:  0.99999833
p_ni:  0.000001668
p_wrong:  2e-9
Data Source:  BioPlex
WDR37
Tbio
Novelty:  0.1677975
p_int:  0.999996364
p_ni:  0.000003636
Data Source:  BioPlex
PACS2
Tbio
Novelty:  0.00887813
p_int:  0.99994753
p_ni:  0.00005035
p_wrong:  0.00000212
Data Source:  BioPlex
RMND1
Tbio
Novelty:  0.06181833
p_int:  0.9880238
p_ni:  0.0119762
Data Source:  BioPlex
BTBD1
Tbio
Novelty:  0.19772296
p_int:  0.878506453
p_ni:  0.120535106
p_wrong:  0.000958441
Data Source:  BioPlex
HAMP
Tbio
Novelty:  0.00035828
Score:  0.755
Data Source:  STRINGDB
VGF
Tbio
Novelty:  0.00521876
Score:  0.582
Data Source:  STRINGDB
FOLR2
Tchem
Novelty:  0.00751372
Score:  0.535
Data Source:  STRINGDB
CLDN12
Tbio
Novelty:  0.04404633
Score:  0.471
Data Source:  STRINGDB
PHKA2
Tbio
Family:  Kinase
Novelty:  0.00461145
Score:  0.461
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
1
1
68
glomerular filtration rate
2
1
2
64.9
mosquito bite reaction itch intensity measurement
1
1
1
64
waist circumference
1
2
2
54.1
body height
1
1
1
46.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
68
glomerular filtration rate
2
64.9
mosquito bite reaction itch intensity measurement
1
64
waist circumference
2
54.1
body height
1
46.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
liver enriched antimicrobial peptide 2
VGNC:13538
744360
Macaque
liver enriched antimicrobial peptide 2
709041
Mouse
MGI:2672795
259301
Dog
liver enriched antimicrobial peptide 2
VGNC:42628
609750
Horse
liver enriched antimicrobial peptide 2
VGNC:19625
100629810
Species
Name
OMA
EggNOG
Inparanoid
Chimp
liver enriched antimicrobial peptide 2
Macaque
liver enriched antimicrobial peptide 2
Mouse
Dog
liver enriched antimicrobial peptide 2
Horse
liver enriched antimicrobial peptide 2
Publication Statistics
PubMed Score 80.88
PubMed score by year
PubTator Score 13.16
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title