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Tbio
LDLRAD4
Low-density lipoprotein receptor class A domain-containing protein 4

Protein Summary
Description
Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359446
  • ENSP00000352420
  • ENSG00000168675
  • ENST00000399848
  • ENSP00000382741
  • ENST00000585931
  • ENSP00000466772
  • ENST00000586765
  • ENSP00000474783
  • ENST00000587757
  • ENSP00000466178
  • ENST00000592991
  • ENSP00000466771

Symbol
  • C18orf1
  • C18orf1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
PubMedID
0.89
kinase perturbation
0.84
transcription factor perturbation
0.84
transcription factor
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.13   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.13   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
MAGI1
Tbio
Family:  Enzyme
Novelty:  0.06837323
p_int:  0.99999885
p_ni:  0.000001075
p_wrong:  7.4e-8
Score:  0.173
Data Source:  BioPlex,STRINGDB
STXBP4
Tbio
Novelty:  0.08831326
p_int:  0.999997799
p_ni:  0.000002201
Data Source:  BioPlex
DPY19L1
Tdark
Family:  Enzyme
Novelty:  0.34765717
p_int:  0.999997733
p_ni:  0.000002265
p_wrong:  1e-9
Data Source:  BioPlex
HECW1
Tbio
Family:  Enzyme
Novelty:  0.15200354
p_int:  0.999997184
p_ni:  0.00000159
p_wrong:  0.000001226
Score:  0.216
Data Source:  BioPlex,STRINGDB
ANKRD13D
Tdark
Novelty:  2.14380936
p_int:  0.999996309
p_ni:  0.000003691
Data Source:  BioPlex
SMAD2
Tbio
Family:  TF
Novelty:  0.00040166
p_int:  0.99999565
p_ni:  0.000001944
p_wrong:  0.000002405
Score:  0.763
Data Source:  BioPlex,STRINGDB
SMAD3
Tchem
Family:  TF
Novelty:  0.00048058
p_int:  0.9999935
p_ni:  8.57e-7
p_wrong:  0.000005643
Score:  0.445
Data Source:  BioPlex,STRINGDB
EPN1
Tbio
Novelty:  0.01788784
p_int:  0.999987472
p_ni:  0.000012528
Data Source:  BioPlex
FLCN
Tbio
Novelty:  0.0022007
p_int:  0.99998583
p_ni:  0.000010144
p_wrong:  0.000004026
Score:  0.202
Data Source:  BioPlex,STRINGDB
HECW2
Tbio
Family:  Enzyme
Novelty:  0.07194044
p_int:  0.999981161
p_ni:  0.000018838
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
5
9
99
2
2
1
1
89.3
alkaline phosphatase measurement
2
2
1
5.7
60.8
C-reactive protein measurement
1
1
1
46.1
platelet crit
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
9
99
1
1
89.3
alkaline phosphatase measurement
1
5.7
60.8
C-reactive protein measurement
1
46.1
platelet crit
1
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
low density lipoprotein receptor class A domain containing 4
701919
Mouse
MGI:1277150
52662
Rat
RGD:1587105
679578
Dog
low density lipoprotein receptor class A domain containing 4
VGNC:42625
483983
Horse
low density lipoprotein receptor class A domain containing 4 [Source:HGNC Symbol;Acc:HGNC:1224]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
low density lipoprotein receptor class A domain containing 4
Mouse
Rat
Dog
low density lipoprotein receptor class A domain containing 4
Horse
low density lipoprotein receptor class A domain containing 4 [Source:HGNC Symbol;Acc:HGNC:1224]
Publication Statistics
PubMed Score 16.13
PubMed score by year
PubTator Score 12.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title