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Tbio
LDHD
Probable D-lactate dehydrogenase, mitochondrial

Protein Summary
Description
The protein encoded by this gene belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. The similar protein in yeast has both D-lactate and D-glycerate dehydrogenase activities. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300051
  • ENSP00000300051
  • ENSG00000166816
  • ENST00000450168
  • ENSP00000417011

Symbol
  • DLD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
molecular function
0.73
cellular component
0.57
transcription factor
0.5
cell type or tissue
0.49


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.25   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 211   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.25   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 211   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (86)
GSTK1
Tchem
Family:  Enzyme
Novelty:  0.04205366
p_int:  0.992662901
p_ni:  0.007336844
p_wrong:  2.55e-7
Data Source:  BioPlex
NDUFAF5
Tbio
Family:  Enzyme
Novelty:  0.13483499
p_int:  0.965411842
p_ni:  0.033904291
p_wrong:  0.000683867
Data Source:  BioPlex
NDUFAF7
Tbio
Family:  Enzyme
Novelty:  0.24691414
p_int:  0.963147412
p_ni:  0.036843389
p_wrong:  0.000009199
Data Source:  BioPlex
ACOT2
Tbio
Family:  Enzyme
Novelty:  0.03086222
p_int:  0.879433529
p_ni:  0.12056647
p_wrong:  1e-9
Data Source:  BioPlex
ZMYM2
Tbio
Novelty:  0.0258698
p_int:  0.824841238
p_ni:  0.175158762
Data Source:  BioPlex
SIRT3
Tchem
Family:  Epigenetic
Novelty:  0.00101187
p_int:  0.789251853
p_ni:  0.20958452
p_wrong:  0.001163627
Data Source:  BioPlex
LDHA
Tchem
Family:  Enzyme
Novelty:  0.0007041
Score:  0.969
Data Source:  STRINGDB
LDHAL6B
Tbio
Family:  Enzyme
Novelty:  0.00801753
Score:  0.963
Data Source:  STRINGDB
LDHB
Tchem
Family:  Enzyme
Novelty:  0.00242213
Score:  0.954
Data Source:  STRINGDB
LDHC
Tbio
Family:  Enzyme
Novelty:  0.00213484
Score:  0.951
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (33)
Mitochondrial protein import (R-HSA-1268020)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Mitochondrial protein import
Protein localization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
5
3
1.2
96.1
3
3
1
1.3
84
lymphocyte count
2
2
2
77.8
1
1
0
1.4
30.2
body weights and measures
1
1
1
17.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.2
96.1
1
1.3
84
lymphocyte count
2
77.8
0
1.4
30.2
body weights and measures
1
17.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lactate dehydrogenase D
VGNC:13729
454245
Macaque
lactate dehydrogenase D
713589
Mouse
MGI:106428
52815
Rat
RGD:1308107
307858
Dog
lactate dehydrogenase D
VGNC:42621
610390
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lactate dehydrogenase D
Macaque
lactate dehydrogenase D
Mouse
Rat
Dog
lactate dehydrogenase D
Publication Statistics
PubMed Score 46.25
PubMed score by year
PubTator Score 55.41
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title