Tbio LDHD Probable D-lactate dehydrogenase, mitochondrial

Protein Summary

Description

The protein encoded by this gene belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. The similar protein in yeast has both D-lactate and D-glycerate dehydrogenase activities. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q86WU2
• Q8IZK5
• DLD

Gene Name

• LDHD

Ensembl ID

• ENST00000300051
• ENSP00000300051
• ENSG00000166816
• ENST00000450168
• ENSP00000417011

Symbol

• DLD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
molecular function	0.73
cellular component	0.57
transcription factor	0.5
cell type or tissue	0.49

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Dehydrogenase / Probable D-lactate Dehydrogenase, Mitochondrial

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Probable D-lactate Dehydrogenase, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.78   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 211   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.78   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 211   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0