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Tbio
LDHC
L-lactate dehydrogenase C chain

Protein Summary
Description
Possible role in sperm motility. Lactate dehydrogenase C catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. LDHC is testis-specific and belongs to the lactate dehydrogenase family. Two transcript variants have been detected which differ in the 5' untranslated region. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280704
  • ENSP00000280704
  • ENSG00000166796
  • ENST00000541669
  • ENSP00000437783

Symbol
  • LDH3
  • LDHX
  • CT32
  • LDH3
  • LDHX
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
cell type or tissue
0.89
kinase perturbation
0.76
biological process
0.71
gene perturbation
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 466.59   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 230   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 466.59   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 230   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (139)
LDHA
Tchem
Family:  Enzyme
Novelty:  0.0007041
p_int:  0.999999996
p_ni:  4e-9
Score:  0.914
Data Source:  BioPlex,STRINGDB
LDHB
Tchem
Family:  Enzyme
Novelty:  0.00242213
p_int:  0.999999943
p_ni:  5.7e-8
Score:  0.914
Data Source:  BioPlex,STRINGDB
TLE3
Tbio
Novelty:  0.02641884
p_int:  0.967096659
p_ni:  0.026548543
p_wrong:  0.006354798
Data Source:  BioPlex
EIPR1
Tbio
Novelty:  0.08803081
p_int:  0.921626306
p_ni:  0.078372851
p_wrong:  8.44e-7
Score:  0.179
Data Source:  BioPlex,STRINGDB
ELMOD1
Tbio
Novelty:  0.28255275
p_int:  0.915441499
p_ni:  0.078184395
p_wrong:  0.006374106
Score:  0.416
Data Source:  BioPlex,STRINGDB
LDHD
Tbio
Family:  Enzyme
Novelty:  0.0230704
Score:  0.951
Data Source:  STRINGDB
PC
Tbio
Family:  Enzyme
Novelty:  0.00271694
Score:  0.942
Data Source:  STRINGDB
ME2
Tbio
Novelty:  0.03635548
Score:  0.942
Data Source:  STRINGDB
GOT1
Tbio
Family:  Enzyme
Novelty:  0.00448817
Score:  0.93
Data Source:  STRINGDB
PKLR
Tbio
Family:  Kinase
Novelty:  0.00268398
Score:  0.925
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (20)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Pyruvate metabolism
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Metabolism
Pyruvate metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle
The citric acid (TCA) cycle and respiratory electron transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum amyloid A protein measurement
1
2
2
95.2
blood metabolite measurement
1
1
1
81.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum amyloid A protein measurement
2
95.2
blood metabolite measurement
1
81.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lactate dehydrogenase C
VGNC:3111
451064
Macaque
lactate dehydrogenase C
693731
Mouse
MGI:96764
16833
Dog
lactate dehydrogenase C
VGNC:52264
476883
Horse
L-lactate dehydrogenase C chain
100057054
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lactate dehydrogenase C
Macaque
lactate dehydrogenase C
Mouse
Dog
lactate dehydrogenase C
Horse
L-lactate dehydrogenase C chain
Publication Statistics
PubMed Score 466.59
PubMed score by year
PubTator Score 224.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title