LDHB
L-lactate dehydrogenase B chain
Protein Summary
This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13. [provided by RefSeq, Feb 2016]
- ENST00000350669
- ENSP00000229319
- ENSG00000111716
- ENST00000396076
- ENSP00000379386
- LDH-B
- LDH-H
- LDHBD
- TRG-5
- HEL-S-281
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
kinase perturbation | 1 | ||
PubMedID | 1 | ||
transcription factor perturbation | 1 | ||
disease perturbation | 0.96 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 414.17 (req: < 5)
Gene RIFs: 34 (req: <= 3)
Antibodies: 392 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 414.17 (req: >= 5)
Gene RIFs: 34 (req: > 3)
Antibodies: 392 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 62
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (62)
Protein-Protein Interactions (229)
Nearest Tclin Targets
Pathways (22)
Reactome (4)
KEGG (8)
PathwayCommons (6)
UniProt (1)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Pyruvate metabolism | ||||
Reactome | Pyruvate metabolism and Citric Acid (TCA) cycle | ||||
Reactome | The citric acid (TCA) cycle and respiratory electron transport | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Pyruvate metabolism | ||||
Pyruvate metabolism and Citric Acid (TCA) cycle | ||||
The citric acid (TCA) cycle and respiratory electron transport | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (2)
Components (5)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Disease Associations ()
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
bilirubin measurement | 2 | 3 | 6 | 81.7 | |||||
serum gamma-glutamyl transferase measurement | 1 | 1 | 1 | 72.3 | |||||
hemoglobin measurement | 2 | 2 | 2 | 66.6 | |||||
C-reactive protein measurement | 1 | 1 | 1 | 57.8 | |||||
mean platelet volume | 1 | 1 | 1 | 45.7 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
bilirubin measurement | 6 | 81.7 | |||||
serum gamma-glutamyl transferase measurement | 1 | 72.3 | |||||
hemoglobin measurement | 2 | 66.6 | |||||
C-reactive protein measurement | 1 | 57.8 | |||||
mean platelet volume | 1 | 45.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | lactate dehydrogenase B | VGNC:5449 | 465337 | |||||
Mouse | MGI:96763 | 16832 | ||||||
Rat | RGD:2997 | 24534 | ||||||
Dog | lactate dehydrogenase B | 477675 | ||||||
Horse | lactate dehydrogenase B | VGNC:19619 | 100033997 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | lactate dehydrogenase B | |||||
Mouse | ||||||
Rat | ||||||
Dog | lactate dehydrogenase B | |||||
Horse | lactate dehydrogenase B | |||||
Publication Statistics
PubMed Score 414.17
PubMed score by year
PubTator Score 167.64
PubTator score by year
Related Publications
Text Mined References (72)
GeneRif Annotations (34)
Items per page:
0 of 0
PMID | Year | Title |
|---|