LDHB
L-lactate dehydrogenase B chain
Protein Summary
This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13. [provided by RefSeq, Feb 2016]
- ENST00000350669
- ENSP00000229319
- ENSG00000111716
- ENST00000396076
- ENSP00000379386
- LDH-B
- LDH-H
- LDHBD
- TRG-5
- HEL-S-281
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
kinase perturbation | 1 | ||
PubMedID | 1 | ||
transcription factor perturbation | 1 | ||
disease perturbation | 0.96 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 470.56 (req: < 5)
Gene RIFs: 50 (req: <= 3)
Antibodies: 392 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 470.56 (req: >= 5)
Gene RIFs: 50 (req: > 3)
Antibodies: 392 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 63
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0