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Tchem
LDHA
L-lactate dehydrogenase A chain

Protein Summary
Description
The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000227157
  • ENSP00000227157
  • ENSG00000134333
  • ENST00000379412
  • ENSP00000368722
  • ENST00000396222
  • ENSP00000379524
  • ENST00000422447
  • ENSP00000395337
  • ENST00000430553
  • ENSP00000406172
  • ENST00000540430
  • ENSP00000445175
  • ENST00000542179
  • ENSP00000445331

Symbol
  • LDHM
  • GSD11
  • PIG19
  • HEL-S-133P
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
protein complex
1
virus perturbation
0.98
kinase perturbation
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1708.24   (req: < 5)
Gene RIFs: 123   (req: <= 3)
Antibodies: 810   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1708.24   (req: >= 5)
Gene RIFs: 123   (req: > 3)
Antibodies: 810   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 287
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (291)
LDHC
Tbio
Family:  Enzyme
Novelty:  0.00213484
p_int:  0.999999996
p_ni:  4e-9
Score:  0.914
Data Source:  BioPlex,STRINGDB
LDHB
Tchem
Family:  Enzyme
Novelty:  0.00242213
p_int:  0.999166363
p_ni:  0.000833637
Score:  0.994
Data Source:  BioPlex,Reactome,STRINGDB
HIF1A
Tchem
Family:  TF
Novelty:  0.00011503
Score:  0.979
Data Source:  STRINGDB
PKM
Tchem
Family:  Kinase
Novelty:  0.00076567
Score:  0.977
Data Source:  STRINGDB
ME2
Tbio
Novelty:  0.03635548
Score:  0.971
Data Source:  STRINGDB
LDHD
Tbio
Family:  Enzyme
Novelty:  0.0230704
Score:  0.969
Data Source:  STRINGDB
PC
Tbio
Family:  Enzyme
Novelty:  0.00271694
Score:  0.965
Data Source:  STRINGDB
ARNT
Tbio
Family:  TF
Novelty:  0.00183071
Score:  0.959
Data Source:  STRINGDB
GPI
Tbio
Family:  Enzyme
Novelty:  0.00095404
Score:  0.945
Data Source:  STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.945
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (31)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Pyruvate metabolism
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Metabolism
Pyruvate metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle
The citric acid (TCA) cycle and respiratory electron transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum amyloid A protein measurement
1
3
3
99
blood metabolite measurement
2
2
2
94.5
metabolite measurement
1
1
1
87.9
blood protein measurement
2
2
1
1.4
84.9
serum amyloid A-1 protein measurement
1
2
2
81.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum amyloid A protein measurement
3
99
blood metabolite measurement
2
94.5
metabolite measurement
1
87.9
blood protein measurement
1
1.4
84.9
serum amyloid A-1 protein measurement
2
81.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lactate dehydrogenase A
VGNC:1085
451063
Macaque
lactate dehydrogenase A
694309
Mouse
MGI:96759
16828
Rat
RGD:2996
24533
Dog
lactate dehydrogenase A
476882
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lactate dehydrogenase A
Macaque
lactate dehydrogenase A
Mouse
Rat
Dog
lactate dehydrogenase A
Publication Statistics
PubMed Score 1708.24
PubMed score by year
PubTator Score 377.05
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title