You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
LDB3
LIM domain-binding protein 3

Protein Summary
Description
May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton. This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-term ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263066
  • ENSP00000263066
  • ENSG00000122367
  • ENST00000361373
  • ENSP00000355296
  • ENST00000372056
  • ENSP00000361126
  • ENST00000372066
  • ENSP00000361136
  • ENST00000429277
  • ENSP00000401437
  • ENST00000623007
  • ENSP00000485389
  • ENST00000623056
  • ENSP00000485500

Symbol
  • KIAA0613
  • ZASP
  • MFM4
  • ZASP
  • CMD1C
  • CMH24
  • CMPD3
  • LVNC3
  • CYPHER
  • LDB3Z1
  • LDB3Z4
  • ORACLE
  • PDLIM6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.91
microRNA
0.82
disease perturbation
0.62
phenotype
0.62
transcription factor perturbation
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.99   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 237   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.99   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 237   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0