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Tbio
LDB2
LIM domain-binding protein 2

Protein Summary
Description
Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. The protein encoded by this gene belongs to the LIM-domain binding family. Members of this family are characterized by a conserved nuclear localization sequence, an amino-terminal homodimerization domain and a carboxy-terminal LIM interaction domain. These proteins function as adapter molecules to allow assembly of transcriptional regulatory complexes. Genetic association studies suggest functions for this gene in rhegmatogenous retinal detachment and coronary artery disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304523
  • ENSP00000306772
  • ENSG00000169744
  • ENST00000441778
  • ENSP00000392089

Symbol
  • CLIM1
  • LDB1
  • CLIM1
  • LDB-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
cell type or tissue
0.77
PubMedID
0.74
disease
0.63
gene perturbation
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.84   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 226   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.84   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (83)
LMO2
Tbio
Novelty:  0.0038279
Score:  0.978
Data Source:  STRINGDB
LMO1
Tbio
Novelty:  0.01670419
Score:  0.923
Data Source:  STRINGDB
SSBP3
Tbio
Novelty:  0.01955714
Score:  0.908
Data Source:  STRINGDB
TCF3
Tbio
Family:  TF
Novelty:  0.00112675
Score:  0.902
Data Source:  STRINGDB
LMO3
Tbio
Novelty:  0.03437083
Score:  0.89
Data Source:  STRINGDB
TAL1
Tbio
Family:  TF
Novelty:  0.00294416
Score:  0.883
Data Source:  STRINGDB
GATA1
Tbio
Family:  TF
Novelty:  0.00077901
Score:  0.874
Data Source:  STRINGDB
NHLH2
Tbio
Family:  TF
Novelty:  0.04744703
Score:  0.81
Data Source:  STRINGDB
LHX6
Tbio
Family:  TF
Novelty:  0.01603143
Score:  0.769
Data Source:  STRINGDB
TCF12
Tbio
Family:  TF
Novelty:  0.00381424
Score:  0.764
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
5.8
29
body mass index
1
1
1
29
risky sexual behaviour measurement
1
1
1
24.5
chronotype measurement
1
1
1
0.8
intelligence
1
1
0
5.5
0.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
5.8
29
body mass index
1
29
risky sexual behaviour measurement
1
24.5
chronotype measurement
1
0.8
intelligence
0
5.5
0.3
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LIM domain binding 2
VGNC:626
745631
Macaque
LIM domain binding 2
714918
Mouse
MGI:894670
16826
Rat
RGD:1307921
289664
Dog
LIM domain binding 2
VGNC:42619
479084
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LIM domain binding 2
Macaque
LIM domain binding 2
Mouse
Rat
Dog
LIM domain binding 2
Publication Statistics
PubMed Score 67.84
PubMed score by year
PubTator Score 5.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title