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Tbio
LCN2
Neutrophil gelatinase-associated lipocalin

Protein Summary
Description
Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development (PubMed:12453413, PubMed:27780864, PubMed:20581821). Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while ir ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000277480
  • ENSP00000277480
  • ENSG00000148346
  • ENST00000373017
  • ENSP00000362108

Symbol
  • HNL
  • NGAL
  • p25
  • 24p3
  • MSFI
  • NGAL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
gene perturbation
0.92
protein domain
0.85
biological process
0.78
small molecule perturbation
0.73


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3673.53   (req: < 5)
Gene RIFs: 599   (req: <= 3)
Antibodies: 1487   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3673.53   (req: >= 5)
Gene RIFs: 599   (req: > 3)
Antibodies: 1487   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (209)
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.999989734
p_ni:  0.000010223
p_wrong:  4.3e-8
Data Source:  BioPlex
DDX31
Tbio
Family:  Enzyme
Novelty:  2.84646195
p_int:  0.999966637
p_ni:  0.00003292
p_wrong:  4.43e-7
Data Source:  BioPlex
KIR3DS1
Tdark
p_int:  0.999928771
p_ni:  0.000071229
Data Source:  BioPlex
TEFM
Tbio
Novelty:  0.10836617
p_int:  0.999919543
p_ni:  0.000080457
Data Source:  BioPlex
PDE4DIP
Tbio
Novelty:  0.03414104
p_int:  0.999890552
p_ni:  0.000109448
Data Source:  BioPlex
NPPA
Tchem
Novelty:  0.00046693
p_int:  0.999838423
p_ni:  0.00016157
p_wrong:  8e-9
Score:  0.174
Data Source:  BioPlex,STRINGDB
SINHCAF
Tdark
Novelty:  0.18692832
p_int:  0.999828265
p_ni:  0.000171732
p_wrong:  3e-9
Data Source:  BioPlex
ITGA9
Tbio
Novelty:  0.01488635
p_int:  0.999211206
p_ni:  0.0007887
p_wrong:  9.4e-8
Score:  0.194
Data Source:  BioPlex,STRINGDB
KLHL11
Tbio
Novelty:  0.1537041
p_int:  0.997051145
p_ni:  0.002948854
p_wrong:  1e-9
Data Source:  BioPlex
DDX19B
Tbio
Family:  Enzyme
Novelty:  0.0504568
p_int:  0.99684281
p_ni:  0.003150986
p_wrong:  0.000006204
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Interleukin-4 and Interleukin-13 signaling
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Cytokine Signaling in Immune system
Immune System
Innate Immune System
Interleukin-4 and Interleukin-13 signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (32)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
42.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lipocalin 2
VGNC:4777
464764
Macaque
lipocalin 2
697208
Mouse
MGI:96757
16819
Rat
RGD:69408
170496
Dog
lipocalin 2
VGNC:42612
491320
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lipocalin 2
Macaque
lipocalin 2
Mouse
Rat
Dog
lipocalin 2
Publication Statistics
PubMed Score 3673.53
PubMed score by year
PubTator Score 1797.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title