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Tdark
LCN10
Epididymal-specific lipocalin-10

Protein Summary
Description
May play a role in male fertility. May act as a retinoid carrier protein within the epididymis. Members of the lipocalin family, such as LCN10, have a common structure consisting of an 8-stranded antiparallel beta-barrel that forms a cup-shaped ligand-binding pocket or calyx. Lipocalins generally bind small hydrophobic ligands and transport them to specific cells (Suzuki et al., 2004 [PubMed 15363845]).[supplied by OMIM, Aug 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000474369
  • ENSP00000420564
  • ENSG00000187922
  • ENST00000497771
  • ENSP00000418491
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.73
cell type or tissue
0.48
cell line
0.47
protein domain
0.41
transcription factor
0.36


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.32   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 60   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.32   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 60   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (19)
LCN6
Tbio
Novelty:  0.11406686
Score:  0.878
Data Source:  STRINGDB
OBP2A
Tbio
Novelty:  0.02757821
Score:  0.65
Data Source:  STRINGDB
LCN9
Tdark
Novelty:  0.25490072
Score:  0.607
Data Source:  STRINGDB
LCN12
Tdark
Novelty:  0.31492521
Score:  0.603
Data Source:  STRINGDB
OBP2B
Tdark
Novelty:  0.43500456
Score:  0.586
Data Source:  STRINGDB
LCN8
Tbio
Novelty:  0.02098116
Score:  0.577
Data Source:  STRINGDB
LCNL1
Tdark
Novelty:  7.94657763
Score:  0.571
Data Source:  STRINGDB
OR2T2
Tdark
Family:  oGPCR
Novelty:  2.79047527
Score:  0.511
Data Source:  STRINGDB
VXN
Tdark
Novelty:  1.04771935
Score:  0.457
Data Source:  STRINGDB
TMEM9
Tbio
Novelty:  0.06916197
Score:  0.453
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
1
1
51
mean reticulocyte volume
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
51
mean reticulocyte volume
1
29
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
lipocalin 10
721700
Mouse
MGI:1925000
332578
Rat
RGD:1564362
499756
Horse
lipocalin 10 [Source:HGNC Symbol;Acc:HGNC:20892]
Cow
lipocalin 10 [Source:HGNC Symbol;Acc:HGNC:20892]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
lipocalin 10
Mouse
Rat
Horse
lipocalin 10 [Source:HGNC Symbol;Acc:HGNC:20892]
Cow
lipocalin 10 [Source:HGNC Symbol;Acc:HGNC:20892]
Publication Statistics
PubMed Score 3.32
PubMed score by year
PubTator Score 0.11
PubTator score by year
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Related Publications
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PMID
Year
Title