LCLAT1
Lysocardiolipin acyltransferase 1
Protein Summary
Acyl-CoA:lysocardiolipin acyltransferase. Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities. Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors. Acts as a remodeling enzyme for cardiolipin, a major membrane polyglycerophospholipid. Converts lysophosphatidic acid (LPA) into phosphatidic acid (PA) with a relatively low activity. Required for establishment of the hematopoietic and endothelial lineages.
- ENST00000309052
- ENSP00000310551
- ENSG00000172954
- ENST00000319406
- ENSP00000368826
- ENST00000379509
- ENSP00000368823
- AGPAT8
- ALCAT1
- LYCAT
- LYCAT
- AGPAT8
- ALCAT1
- 1AGPAT8
- UNQ1849
- HSRG1849
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.86 | ||
microRNA | 0.77 | ||
kinase perturbation | 0.76 | ||
cell type or tissue | 0.71 | ||
transcription factor binding site profile | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 42.22 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 91 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 42.22 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 91 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0