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Tbio
LCLAT1
Lysocardiolipin acyltransferase 1

Protein Summary
Description
Acyl-CoA:lysocardiolipin acyltransferase. Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities. Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors. Acts as a remodeling enzyme for cardiolipin, a major membrane polyglycerophospholipid. Converts lysophosphatidic acid (LPA) into phosphatidic acid (PA) with a relatively low activity. Required for establishment of the hematopoietic and endothelial lineages.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309052
  • ENSP00000310551
  • ENSG00000172954
  • ENST00000319406
  • ENSP00000368826
  • ENST00000379509
  • ENSP00000368823

Symbol
  • AGPAT8
  • ALCAT1
  • LYCAT
  • LYCAT
  • AGPAT8
  • ALCAT1
  • 1AGPAT8
  • UNQ1849
  • HSRG1849
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
microRNA
0.77
kinase perturbation
0.76
cell type or tissue
0.71
transcription factor binding site profile
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.46   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.46   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (99)
FRMD3
Tbio
Novelty:  0.07186065
p_int:  0.999694091
p_ni:  0.000305909
Score:  0.173
Data Source:  BioPlex,STRINGDB
PRRT2
Tbio
Novelty:  0.00442931
p_int:  0.990896553
p_ni:  0.009103447
Score:  0.169
Data Source:  BioPlex,STRINGDB
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
p_int:  0.984567953
p_ni:  0.015431935
p_wrong:  1.12e-7
Data Source:  BioPlex
ADAM32
Tdark
Family:  Enzyme
Novelty:  0.36071191
p_int:  0.983541371
p_ni:  0.016458629
Score:  0.209
Data Source:  BioPlex,STRINGDB
NKAIN1
Tdark
Family:  Enzyme
Novelty:  0.52190272
p_int:  0.983302993
p_ni:  0.016689473
p_wrong:  0.000007534
Data Source:  BioPlex
TMEM63C
Tdark
Family:  IC
Novelty:  0.02849254
p_int:  0.955364429
p_ni:  0.04377773
p_wrong:  0.000857841
Data Source:  BioPlex
TSPAN5
Tbio
Novelty:  0.08879443
p_int:  0.945466673
p_ni:  0.054533325
p_wrong:  2e-9
Data Source:  BioPlex
DLK2
Tbio
Novelty:  0.06366405
p_int:  0.943114599
p_ni:  0.056882988
p_wrong:  0.000002413
Data Source:  BioPlex
CHRND
Tclin
Family:  IC
Novelty:  0.0441685
p_int:  0.939250941
p_ni:  0.060746516
p_wrong:  0.000002543
Data Source:  BioPlex
CCR6
Tchem
Family:  GPCR
Novelty:  0.00257933
p_int:  0.93795437
p_ni:  0.061758803
p_wrong:  0.000286827
Data Source:  BioPlex
Nearest Tclin Targets (4)
Explore Nearest Tclin Targets
1 – 3 of 3
LIPF
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
PNLIP
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
DGAT1
Tclin
Family:  Enzyme
KEGG Distance:  2
Common Pathways:  2
Pathways (13)
Acyl chain remodeling of CL (R-HSA-1482798)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodeling of CL
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Name
Explore in Pharos
Explore in Source
Acyl chain remodeling of CL
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
2
1
7.7
82
balding measurement
1
1
1
33
testosterone measurement
1
1
1
0.9
1
1
1
0.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
7.7
82
balding measurement
1
33
testosterone measurement
1
0.9
1
0.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysocardiolipin acyltransferase 1
VGNC:287
459129
Mouse
MGI:2684937
225010
Rat
RGD:1565906
362702
Dog
lysocardiolipin acyltransferase 1
VGNC:42608
483023
Horse
lysocardiolipin acyltransferase 1
VGNC:19608
100070805
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysocardiolipin acyltransferase 1
Mouse
Rat
Dog
lysocardiolipin acyltransferase 1
Horse
lysocardiolipin acyltransferase 1
Publication Statistics
PubMed Score 35.46
PubMed score by year
PubTator Score 6.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title