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Tclin
LCK
Tyrosine-protein kinase Lck

Protein Summary
Description
Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, u ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333070
  • ENSP00000328213
  • ENSG00000182866
  • ENST00000336890
  • ENSP00000337825
  • ENST00000619559
  • ENSP00000477713

Symbol
  • LSK
  • YT16
  • IMD22
  • p56lck
  • pp58lck
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
molecular function
1
small molecule
1
protein domain
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1672.53   (req: < 5)
Gene RIFs: 145   (req: <= 3)
Antibodies: 1561   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1672.53   (req: >= 5)
Gene RIFs: 145   (req: > 3)
Antibodies: 1561   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 42
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 560
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 10
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (10)
bosutinib
Rendered image for bosutinib
dasatinib
Rendered image for dasatinib
sunitinib
Rendered image for sunitinib
nintedanib
Rendered image for nintedanib
ponatinib
Rendered image for ponatinib
ibrutinib
Rendered image for ibrutinib
acalabrutinib
Rendered image for acalabrutinib
pazopanib
Rendered image for pazopanib
vandetanib
Rendered image for vandetanib
pexidartinib
Rendered image for pexidartinib
Protein-Protein Interactions (468)
CD4
Tclin
Novelty:  0.00001217
Score:  0.998
Data Source:  Reactome,STRINGDB
PTPRC
Tchem
Family:  Enzyme
Novelty:  0.00012027
Score:  0.994
Data Source:  Reactome,STRINGDB
CD8A
Tbio
Novelty:  0.00002519
Score:  0.994
Data Source:  STRINGDB
VAV1
Tchem
Novelty:  0.00180518
Score:  0.992
Data Source:  Reactome,STRINGDB
LAT
Tbio
Novelty:  0.00738419
Score:  0.991
Data Source:  Reactome,STRINGDB
CD247
Tbio
Novelty:  0.00217194
Score:  0.991
Data Source:  Reactome,STRINGDB
CD28
Tbio
Novelty:  0.00036482
Score:  0.99
Data Source:  Reactome,STRINGDB
CTLA4
Tclin
Novelty:  0.00012781
Score:  0.989
Data Source:  STRINGDB
LCP2
Tbio
Novelty:  0.00512968
Score:  0.989
Data Source:  Reactome,STRINGDB
CD3E
Tclin
Novelty:  0.0053855
Score:  0.987
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (106)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 44
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
CD28 co-stimulation
Reactome
CD28 dependent PI3K/Akt signaling
Reactome
CD28 dependent Vav1 pathway
Reactome
CTLA4 inhibitory signaling
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CTLA4 inhibitory signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (49)
Find Similar Targets
Items per page:
10
1 – 10 of 18
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
viral load
1
1
1
66
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
viral load
1
66
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LCK proto-oncogene, Src family tyrosine kinase
VGNC:11499
456715
Mouse
MGI:96756
16818
Rat
RGD:2994
313050
Dog
LCK proto-oncogene, Src family tyrosine kinase
VGNC:42607
478151
Horse
LCK proto-oncogene, Src family tyrosine kinase
VGNC:19607
100146139
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LCK proto-oncogene, Src family tyrosine kinase
Mouse
Rat
Dog
LCK proto-oncogene, Src family tyrosine kinase
Horse
LCK proto-oncogene, Src family tyrosine kinase
Publication Statistics
PubMed Score 1672.53
PubMed score by year
PubTator Score 844.11
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title