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Tbio
LCE3C
Late cornified envelope protein 3C

Protein Summary
Description
A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens (PubMed:28634035).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333881
  • ENSP00000334644
  • ENSG00000244057

Symbol
  • LEP15
  • SPRL3A
  • LEP15
  • SPRL3A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.46
transcription factor
0.44
biological term
0.42
disease
0.4
protein complex
0.4


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.4   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 21   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.4   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 21   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (76)
LCE1B
Tbio
Novelty:  0.06933554
Score:  0.988
Data Source:  STRINGDB
LCE1A
Tbio
Novelty:  0.04596696
Score:  0.977
Data Source:  STRINGDB
LCE1D
Tbio
Novelty:  0.52901166
Score:  0.954
Data Source:  STRINGDB
LCE2D
Tdark
Novelty:  1.74927
Score:  0.951
Data Source:  STRINGDB
IVL
Tbio
Novelty:  0.00147892
Score:  0.951
Data Source:  STRINGDB
LOR
Tbio
Novelty:  0.0033781
Score:  0.95
Data Source:  STRINGDB
LCE6A
Tdark
Novelty:  2.0416597
Score:  0.947
Data Source:  STRINGDB
LCE1F
Tdark
Novelty:  1.56312927
Score:  0.945
Data Source:  STRINGDB
LCE2C
Tdark
Novelty:  4.51851552
Score:  0.945
Data Source:  STRINGDB
RPTN
Tbio
Novelty:  0.08523633
Score:  0.944
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
6
0
1.3
98.7
2
2
0
1.8
94.3
vitamin D measurement
2
2
2
85.3
1
2
0
1.4
84.1
type 2 diabetes mellitus
1
1
0
1.1
35.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
98.7
0
1.8
94.3
vitamin D measurement
2
85.3
0
1.4
84.1
type 2 diabetes mellitus
0
1.1
35.6
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 23.40
PubMed score by year
PubTator Score 15.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title