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Tchem
LCAT
Phosphatidylcholine-sterol acyltransferase

Protein Summary
Description
Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs) (PubMed:10329423, PubMed:19065001, PubMed:26195816). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107). Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (PubMed:10722751). This gene encodes the extracellular ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264005
  • ENSP00000264005
  • ENSG00000213398
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.81
biological process
0.69
co-expressed gene
0.69
disease
0.69
chemical
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 282.69   (req: < 5)
Gene RIFs: 86   (req: <= 3)
Antibodies: 378   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 282.69   (req: >= 5)
Gene RIFs: 86   (req: > 3)
Antibodies: 378   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 131
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (131)
CHEMBL4571766,CHEMBL4444702
Rendered image for CHEMBL4571766,CHEMBL4444702
CHEMBL4543681
Rendered image for CHEMBL4543681
CHEMBL4444091
Rendered image for CHEMBL4444091
CHEMBL4567833
Rendered image for CHEMBL4567833
CHEMBL4449961
Rendered image for CHEMBL4449961
CHEMBL4438875
Rendered image for CHEMBL4438875
CHEMBL4565710
Rendered image for CHEMBL4565710
CHEMBL4565889
Rendered image for CHEMBL4565889
CHEMBL4475628
Rendered image for CHEMBL4475628
CHEMBL4449770
Rendered image for CHEMBL4449770
Protein-Protein Interactions (143)
APOA1
Tbio
Novelty:  0.0001216
Score:  0.992
Data Source:  Reactome,STRINGDB
CETP
Tchem
Novelty:  0.00051779
Score:  0.972
Data Source:  STRINGDB
LPA
Tbio
Family:  Enzyme
Novelty:  0.00054858
Score:  0.969
Data Source:  STRINGDB
APOA2
Tbio
Novelty:  0.00117627
Score:  0.966
Data Source:  STRINGDB
PLTP
Tbio
Novelty:  0.00267612
Score:  0.96
Data Source:  STRINGDB
ALB
Tchem
Novelty:  0.00000616
Score:  0.953
Data Source:  STRINGDB
APOB
Tchem
Novelty:  0.00008247
Score:  0.952
Data Source:  STRINGDB
APOE
Tbio
Novelty:  0.00005049
Score:  0.951
Data Source:  STRINGDB
PEMT
Tbio
Family:  Enzyme
Novelty:  0.00786252
Score:  0.94
Data Source:  STRINGDB
PON1
Tbio
Family:  Enzyme
Novelty:  0.00033137
Score:  0.935
Data Source:  STRINGDB
Pathways (9)
HDL remodeling (R-HSA-8964058)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
HDL remodeling
Reactome
Plasma lipoprotein assembly, remodeling, and clearance
Reactome
Plasma lipoprotein remodeling
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
HDL remodeling
Plasma lipoprotein assembly, remodeling, and clearance
Plasma lipoprotein remodeling
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
18
22
38
10
99.5
apolipoprotein A 1 measurement
2
7
7
98.8
mean corpuscular volume
1
2
2
90.6
sleep duration
2
2
3
84.1
red blood cell density measurement
1
1
1
82.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
38
10
99.5
apolipoprotein A 1 measurement
7
98.8
mean corpuscular volume
2
90.6
sleep duration
3
84.1
red blood cell density measurement
1
82.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lecithin-cholesterol acyltransferase
VGNC:5831
743056
Mouse
MGI:96755
16816
Rat
RGD:2993
24530
Dog
lecithin-cholesterol acyltransferase
VGNC:42606
479680
Horse
lecithin-cholesterol acyltransferase
VGNC:19606
100053753
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lecithin-cholesterol acyltransferase
Mouse
Rat
Dog
lecithin-cholesterol acyltransferase
Horse
lecithin-cholesterol acyltransferase
Publication Statistics
PubMed Score 282.69
PubMed score by year
PubTator Score 1479.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title