Tbio LCA5 Lebercilin

Protein Summary

Description

Might be involved in minus end-directed microtubule transport. This gene encodes a protein that is thought to be involved in centrosomal or ciliary functions. Mutations in this gene cause Leber congenital amaurosis type V. Alternatively spliced transcript variants are described. [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• Q86VQ0
• E1P542
• Q9BWX7

Gene Name

• LCA5

Ensembl ID

• ENST00000369846
• ENSP00000358861
• ENSG00000135338
• ENST00000392959
• ENSP00000376686

Symbol

• C6orf152
• C6orf152

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.88
microRNA	0.69
cell line	0.57
gene perturbation	0.53
transcription factor binding site profile	0.53

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.87   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 106   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.87   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0