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Tchem
LATS1
Serine/threonine-protein kinase LATS1

Protein Summary
Description
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negativ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253339
  • ENSP00000253339
  • ENSG00000131023
  • ENST00000392273
  • ENSP00000444678
  • ENST00000543571
  • ENSP00000437550

Symbol
  • WARTS
  • wts
  • WARTS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.97
biological process
0.91
kinase
0.8
histone modification site profile
0.71


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 290.53   (req: < 5)
Gene RIFs: 75   (req: <= 3)
Antibodies: 348   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 290.53   (req: >= 5)
Gene RIFs: 75   (req: > 3)
Antibodies: 348   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 184
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (126)
MOB1B
Tbio
Family:  Enzyme
Novelty:  0.0718959
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CDC42BPA
Tchem
Family:  Kinase
Novelty:  0.02575412
p_int:  0.989021993
p_ni:  0.010978007
Data Source:  BioPlex
TYMS
Tclin
Family:  Enzyme
Novelty:  0.00087522
p_int:  0.976934142
p_ni:  0.023065858
Score:  0.222
Data Source:  BioPlex,STRINGDB
CARM1
Tchem
Family:  Epigenetic
Novelty:  0.00623937
p_int:  0.929900363
p_ni:  0.070099637
Data Source:  BioPlex
MOB1A
Tbio
Family:  Enzyme
Novelty:  0.01430129
Score:  0.999
Data Source:  Reactome,STRINGDB
YAP1
Tchem
Novelty:  0.00124225
Score:  0.999
Data Source:  Reactome,STRINGDB
SAV1
Tbio
Novelty:  0.00962335
Score:  0.998
Data Source:  STRINGDB
WWTR1
Tbio
Novelty:  0.00431186
Score:  0.991
Data Source:  Reactome,STRINGDB
WWC1
Tbio
Novelty:  0.00905646
Score:  0.989
Data Source:  Reactome,STRINGDB
NF2
Tbio
Novelty:  0.00055092
Score:  0.971
Data Source:  STRINGDB
Pathways (19)
Signal Transduction (R-HSA-162582)

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Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Signal Transduction
Reactome
Signaling by Hippo
Name
Explore in Pharos
Explore in Source
Signal Transduction
Signaling by Hippo
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (32)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
brain stem volume measurement
1
1
0
6.7
49.5
1
1
0
1.1
7.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
brain stem volume measurement
0
6.7
49.5
0
1.1
7.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
large tumor suppressor kinase 1
VGNC:3367
748397
Macaque
large tumor suppressor kinase 1
696131
Mouse
MGI:1333883
16798
Rat
RGD:1564085
308265
Dog
large tumor suppressor kinase 1
VGNC:42598
476241
Species
Name
OMA
EggNOG
Inparanoid
Chimp
large tumor suppressor kinase 1
Macaque
large tumor suppressor kinase 1
Mouse
Rat
Dog
large tumor suppressor kinase 1
Publication Statistics
PubMed Score 290.53
PubMed score by year
PubTator Score 107.09
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title