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Tbio
LAT
Linker for activation of T-cells family member 1

Protein Summary
Description
Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. The protein encoded by this gene is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins an ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360872
  • ENSP00000354119
  • ENSG00000213658
  • ENST00000395456
  • ENSP00000378841
  • ENST00000395461
  • ENSP00000378845
  • ENST00000454369
  • ENSP00000398793
  • ENST00000564277
  • ENSP00000457036
  • ENST00000566177
  • ENSP00000456761

Symbol
  • LAT1
  • pp36
  • IMD52
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
hub protein
0.96
biological process
0.88
protein complex
0.87
biological term
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.91   (req: < 5)
Gene RIFs: 68   (req: <= 3)
Antibodies: 918   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.91   (req: >= 5)
Gene RIFs: 68   (req: > 3)
Antibodies: 918   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0