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Tbio
LASP1
LIM and SH3 domain protein 1

Protein Summary
Description
Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal cancer. [provided by RefSeq, Oct 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318008
  • ENSP00000325240
  • ENSG00000002834
  • ENST00000433206
  • ENSP00000401048
  • ENST00000435347
  • ENSP00000392853

Symbol
  • MLN50
  • MLN50
  • Lasp-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
transcription factor binding site profile
0.97
disease perturbation
0.9
virus perturbation
0.88
interacting protein
0.82


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.31   (req: < 5)
Gene RIFs: 65   (req: <= 3)
Antibodies: 379   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 143.31   (req: >= 5)
Gene RIFs: 65   (req: > 3)
Antibodies: 379   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (118)
FAM24B
Tdark
Novelty:  1.04675689
p_int:  0.999548052
p_ni:  0.000451947
p_wrong:  1e-9
Data Source:  BioPlex
ZNF764
Tdark
Family:  TF
Novelty:  0.76308829
p_int:  0.997732315
p_ni:  0.002267685
Data Source:  BioPlex
FYTTD1
Tbio
Novelty:  0.04600073
p_int:  0.98639218
p_ni:  0.01360782
Score:  0.294
Data Source:  BioPlex,STRINGDB
RDH12
Tbio
Family:  Enzyme
Novelty:  0.016003
p_int:  0.985216774
p_ni:  0.014783226
Score:  0.184
Data Source:  BioPlex,STRINGDB
SNRNP27
Tbio
Novelty:  0.0175187
p_int:  0.974568828
p_ni:  0.025431169
p_wrong:  3e-9
Score:  0.162
Data Source:  BioPlex,STRINGDB
THAP8
Tdark
Family:  TF
Novelty:  3.10152067
p_int:  0.964925441
p_ni:  0.035074558
p_wrong:  1e-9
Score:  0.237
Data Source:  BioPlex,STRINGDB
DNAAF2
Tbio
Novelty:  0.01254416
p_int:  0.961985004
p_ni:  0.038014995
p_wrong:  2e-9
Data Source:  BioPlex
HAX1
Tbio
Novelty:  0.00749205
p_int:  0.950610614
p_ni:  0.049389381
p_wrong:  5e-9
Data Source:  BioPlex
SLC25A44
Tdark
Family:  Transporter
Novelty:  0.36924538
p_int:  0.861536952
p_ni:  0.138451071
p_wrong:  0.000011978
Score:  0.353
Data Source:  BioPlex,STRINGDB
NFYA
Tbio
Family:  TF
Novelty:  0.00507094
p_int:  0.861536952
p_ni:  0.138451071
p_wrong:  0.000011978
Score:  0.206
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
45.7
platelet crit
1
1
1
38.8
intraocular pressure measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
45.7
platelet crit
1
38.8
intraocular pressure measurement
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LIM and SH3 protein 1
VGNC:9605
454620
Macaque
LIM and SH3 protein 1
694950
Mouse
MGI:109656
16796
Rat
RGD:68408
29278
Dog
LIM and SH3 protein 1
VGNC:42595
608624
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LIM and SH3 protein 1
Macaque
LIM and SH3 protein 1
Mouse
Rat
Dog
LIM and SH3 protein 1
Publication Statistics
PubMed Score 143.31
PubMed score by year
PubTator Score 97.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title