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Tbio
LARS2
Probable leucine--tRNA ligase, mitochondrial

Protein Summary
Description
This gene encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265537
  • ENSP00000265537
  • ENSG00000011376
  • ENST00000415258
  • ENSP00000408576
  • ENST00000642274
  • ENSP00000495707
  • ENST00000645846
  • ENSP00000495093

Symbol
  • KIAA0028
  • HLASA
  • LEURS
  • PRLTS4
  • mtLeuRS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
histone modification site profile
0.92
protein domain
0.92
transcription factor binding site profile
0.83
kinase perturbation
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 318.4   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 318.4   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (153)
DUSP22
Tbio
Family:  Enzyme
Novelty:  0.01579003
p_int:  0.996462457
p_ni:  0.003537543
Score:  0.179
Data Source:  BioPlex,STRINGDB
NIT1
Tbio
Family:  Enzyme
Novelty:  0.00498587
p_int:  0.995132347
p_ni:  0.004867653
Data Source:  BioPlex
NDUFS7
Tclin
Family:  Enzyme
Novelty:  0.01562198
p_int:  0.972130138
p_ni:  0.027869862
Data Source:  BioPlex
BSG
Tbio
Novelty:  0.0010285
p_int:  0.97025309
p_ni:  0.02974691
Data Source:  BioPlex
YBEY
Tdark
Family:  Enzyme
Novelty:  0.02778029
p_int:  0.961883364
p_ni:  0.038116636
Score:  0.421
Data Source:  BioPlex,STRINGDB
ACSM5
Tbio
Family:  Enzyme
Novelty:  0.11562771
p_int:  0.940606736
p_ni:  0.059393264
Score:  0.186
Data Source:  BioPlex,STRINGDB
BPNT1
Tbio
Family:  Enzyme
Novelty:  0.1114547
p_int:  0.911201067
p_ni:  0.088798932
p_wrong:  1e-9
Data Source:  BioPlex
MRPL21
Tdark
Novelty:  0.56552559
p_int:  0.902308782
p_ni:  0.097691218
Score:  0.397
Data Source:  BioPlex,STRINGDB
GLMP
Tdark
Novelty:  0.10163099
p_int:  0.856536139
p_ni:  0.143463861
Data Source:  BioPlex
ATP5F1D
Tbio
Family:  Enzyme
Novelty:  0.07296539
p_int:  0.842947402
p_ni:  0.157052598
Score:  0.351
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial tRNA aminoacylation
Reactome
Translation
Reactome
tRNA Aminoacylation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial tRNA aminoacylation
Translation
tRNA Aminoacylation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
macrophage inflammatory protein 1b measurement
1
2
2
70
viral load
1
1
1
69.3
CCL2 measurement
1
1
1
19
age at first birth measurement
1
1
1
17.9
blood protein measurement
1
1
1
13.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
macrophage inflammatory protein 1b measurement
2
70
viral load
1
69.3
CCL2 measurement
1
19
age at first birth measurement
1
17.9
blood protein measurement
1
13.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucyl-tRNA synthetase 2, mitochondrial
VGNC:6356
739246
Macaque
leucyl-tRNA synthetase 2, mitochondrial
714224
Mouse
MGI:2142973
102436
Rat
RGD:1308429
363172
Dog
leucyl-tRNA synthetase 2, mitochondrial
VGNC:42593
476652
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucyl-tRNA synthetase 2, mitochondrial
Macaque
leucyl-tRNA synthetase 2, mitochondrial
Mouse
Rat
Dog
leucyl-tRNA synthetase 2, mitochondrial
Publication Statistics
PubMed Score 318.40
PubMed score by year
PubTator Score 29.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title