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Tchem
LARS
Leucine--tRNA ligase, cytoplasmic

Protein Summary
Description
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs. This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. A mutation in this gene was found in affected individuals with infantile liver failure syndrome 1. Alternatively spliced transcript variants of this gene have been observed. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274562
  • ENSP00000274562
  • ENSG00000133706
  • ENST00000394434
  • ENSP00000377954
  • ENST00000510191
  • ENSP00000426005

Symbol
  • KIAA1352
  • LRS
  • LEUS
  • LFIS
  • ILFS1
  • LARS1
  • LEURS
  • PIG44
  • RNTLS
  • HSPC192
  • hr025Cl
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
0.98
protein domain
0.97
molecular function
0.96
virus perturbation
0.88


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 486.97   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 486.97   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0