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Tbio
LARP1B
La-related protein 1B

Protein Summary
Description
This gene encodes a protein containing domains found in the La related protein of Drosophila melanogaster. La motif-containing proteins are thought to be RNA-binding proteins, where the La motif and adjacent amino acids fold into an RNA recognition motif. The La motif is also found in proteins unrelated to the La protein. Alternative splicing has been observed at this locus and multiple variants, encoding distinct isoforms, are described. Additional splice variation has been identified but the full-length nature of these transcripts has not been determined. [provided by RefSeq, Jun 2013]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
transcription factor perturbation
0.8
transcription factor binding site profile
0.71
microRNA
0.67
transcription factor
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.62   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.62   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
LARP4B
Tbio
Novelty:  0.11363794
p_int:  0.996266286
p_ni:  0.003733714
Score:  0.358
Data Source:  BioPlex,STRINGDB
GSPT2
Tchem
Family:  Enzyme
Novelty:  0.08140512
p_int:  0.99267386
p_ni:  0.00732614
Score:  0.348
Data Source:  BioPlex,STRINGDB
LARP1
Tbio
Novelty:  0.0298044
p_int:  0.991805991
p_ni:  0.008194009
Score:  0.813
Data Source:  BioPlex,STRINGDB
ELAVL2
Tbio
Novelty:  0.00370708
p_int:  0.986496867
p_ni:  0.013503133
Score:  0.457
Data Source:  BioPlex,STRINGDB
TRA2A
Tbio
Novelty:  0.04935993
p_int:  0.981594933
p_ni:  0.018405067
Score:  0.26
Data Source:  BioPlex,STRINGDB
HNRNPA1
Tchem
Novelty:  0.0020871
p_int:  0.972863939
p_ni:  0.027136061
Score:  0.199
Data Source:  BioPlex,STRINGDB
CCNI2
Tdark
Novelty:  0.6093503
p_int:  0.968451588
p_ni:  0.031548412
Score:  0.336
Data Source:  BioPlex,STRINGDB
THAP3
Tdark
Family:  TF
Novelty:  0.52942342
p_int:  0.941934715
p_ni:  0.058065285
Data Source:  BioPlex
FGF17
Tbio
Novelty:  0.01432991
p_int:  0.93143555
p_ni:  0.06856445
Data Source:  BioPlex
RNF151
Tdark
Novelty:  2.0077961
p_int:  0.904185801
p_ni:  0.095814199
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
2
2
1
7.4
77.6
sex hormone-binding globulin measurement
3
2
3
67.9
red blood cell distribution width
2
1
2
66.2
serum albumin measurement
1
1
1
48.8
mean corpuscular volume
1
1
1
33.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
1
7.4
77.6
sex hormone-binding globulin measurement
3
67.9
red blood cell distribution width
2
66.2
serum albumin measurement
1
48.8
mean corpuscular volume
1
33.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
La ribonucleoprotein domain family member 1B
693747
Dog
La ribonucleoprotein domain family member 1B
VGNC:42588
476085
Opossum
La ribonucleoprotein domain family member 1B
100011286
Anole lizard
La ribonucleoprotein domain family member 1B
100556713
Xenopus
La ribonucleoprotein domain family member 1B
XB-GENE-5737452
100158557
Species
Name
OMA
EggNOG
Inparanoid
Macaque
La ribonucleoprotein domain family member 1B
Dog
La ribonucleoprotein domain family member 1B
Opossum
La ribonucleoprotein domain family member 1B
Anole lizard
La ribonucleoprotein domain family member 1B
Xenopus
La ribonucleoprotein domain family member 1B
Publication Statistics
PubMed Score 6.62
PubMed score by year
PubTator Score 1.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title