LARGE1
LARGE xylosyl- and glucuronyltransferase 1
Protein Summary
Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:22223806). Phosphorylated O-mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity and plays a key role in skeletal muscle function and regeneration. LARGE elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B3GNT1/B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (PubMed:25279699). This gene encodes a member of the N-acetylglucosaminyltransferase gene family. It encodes a glycosyltransferase which participates in glycosylation of alpha-dystroglycan, and may carry out the synthesis of glycoprotein and gly ...more
- ENST00000354992
- ENSP00000347088
- ENSG00000133424
- ENST00000397394
- ENSP00000380549
- ENST00000402320
- ENSP00000385223
- KIAA0609
- LARGE
- LARGE
- MDC1D
- MDDGA6
- MDDGB6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27.4 (req: < 5)
Gene RIFs: 19 (req: <= 3)
Antibodies: 135 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 27.4 (req: >= 5)
Gene RIFs: 19 (req: > 3)
Antibodies: 135 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (48)
PLAUR
Family: Enzyme
Novelty: 0.00087642
p_int: 0.999981552
p_ni: 0.000018444
p_wrong: 4e-9
Data Source: BioPlex
RLN1
Novelty: 0.03992636
p_int: 0.999860821
p_ni: 0.000137902
p_wrong: 0.000001278
Data Source: BioPlex
SCGB2A1
Novelty: 0.01902973
p_int: 0.999581079
p_ni: 0.000418916
p_wrong: 6e-9
Data Source: BioPlex
TMEM25
Novelty: 0.35505784
p_int: 0.999325701
p_ni: 0.000602168
p_wrong: 0.000072131
Data Source: BioPlex
SCGB2A2
Novelty: 0.01594053
p_int: 0.998881937
p_ni: 0.000814724
p_wrong: 0.000303339
Data Source: BioPlex
SLC3A2
Family: Transporter
Novelty: 0.0021506
p_int: 0.997355128
p_ni: 0.002494237
p_wrong: 0.000150635
Data Source: BioPlex
HYOU1
Novelty: 0.00833649
p_int: 0.996114993
p_ni: 0.003160439
p_wrong: 0.000724569
Data Source: BioPlex
PSCA
Novelty: 0.00323778
p_int: 0.991276921
p_ni: 0.00822602
p_wrong: 0.000497059
Data Source: BioPlex
FAM19A2
Novelty: 0.28999346
p_int: 0.969724884
p_ni: 0.028652918
p_wrong: 0.001622198
Data Source: BioPlex
SLAMF1
Novelty: 0.00112892
p_int: 0.955576446
p_ni: 0.005664659
p_wrong: 0.038758894
Data Source: BioPlex
Nearest Tclin Targets
Pathways (10)
Reactome (7)
KEGG (2)
UniProt (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Defective LARGE causes MDDGA6 and MDDGB6 | ||||
Reactome | Disease | ||||
Reactome | Diseases associated with O-glycosylation of proteins | ||||
Reactome | Diseases of glycosylation | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Defective LARGE causes MDDGA6 and MDDGB6 | ||||
Disease | ||||
Diseases associated with O-glycosylation of proteins | ||||
Diseases of glycosylation | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (6)
Components (3)
Processes (9)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
self reported educational attainment | 2 | 3 | 3 | 81.1 | |||||
mathematical ability | 2 | 2 | 2 | 55.2 | |||||
household income | 1 | 2 | 2 | 29.9 | |||||
intelligence | 2 | 2 | 1 | 5.5 | 26.6 | ||||
neuroticism measurement | 1 | 1 | 1 | 17.8 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
self reported educational attainment | 3 | 81.1 | |||||
mathematical ability | 2 | 55.2 | |||||
household income | 2 | 29.9 | |||||
intelligence | 1 | 5.5 | 26.6 | ||||
neuroticism measurement | 1 | 17.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | LARGE xylosyl- and glucuronyltransferase 1 | VGNC:13835 | 470192 | |||||
Mouse | MGI:1342270 | 16795 | ||||||
Dog | LARGE xylosyl- and glucuronyltransferase 1 | VGNC:42585 | 474521 | |||||
Horse | LARGE xylosyl- and glucuronyltransferase 1 | VGNC:19584 | 100068935 | |||||
Chicken | LARGE xylosyl- and glucuronyltransferase 1 | CGNC:50664 | 418062 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | LARGE xylosyl- and glucuronyltransferase 1 | |||||
Mouse | ||||||
Dog | LARGE xylosyl- and glucuronyltransferase 1 | |||||
Horse | LARGE xylosyl- and glucuronyltransferase 1 | |||||
Chicken | LARGE xylosyl- and glucuronyltransferase 1 | |||||
Publication Statistics
PubMed Score 27.40
PubMed score by year
PubTator Score 23.43
PubTator score by year
Related Publications
Text Mined References (40)
GeneRif Annotations (19)
Items per page:
0 of 0
PMID | Year | Title |
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