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Tchem
LAP3
Cytosol aminopeptidase

Protein Summary
Description
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000226299
  • ENSP00000226299
  • ENSG00000002549
  • ENST00000606142
  • ENSP00000476028
  • ENST00000618908
  • ENSP00000481000

Symbol
  • LAPEP
  • PEPS
  • LAP
  • PEPS
  • LAPEP
  • HEL-S-106
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
disease perturbation
0.87
transcription factor binding site profile
0.79
PubMedID
0.77
kinase perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 307.71   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 218   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 307.71   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 218   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 30
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (123)
ANPEP
Tchem
Family:  Enzyme
Novelty:  0.0004182
Score:  0.939
Data Source:  STRINGDB
GGT5
Tbio
Family:  Enzyme
Novelty:  0.00602505
Score:  0.933
Data Source:  STRINGDB
GGT7
Tbio
Family:  Enzyme
Novelty:  0.01374716
Score:  0.928
Data Source:  STRINGDB
GGT6
Tbio
Family:  Enzyme
Novelty:  0.016069
Score:  0.928
Data Source:  STRINGDB
GGT1
Tbio
Family:  Enzyme
Novelty:  0.00252374
Score:  0.921
Data Source:  STRINGDB
GSS
Tbio
Family:  Enzyme
Novelty:  0.03002278
Score:  0.914
Data Source:  STRINGDB
PYCR1
Tbio
Family:  Enzyme
Novelty:  0.00220832
Score:  0.911
Data Source:  STRINGDB
PYCR3
Tbio
Family:  Enzyme
Novelty:  0.1041757
Score:  0.908
Data Source:  STRINGDB
PYCR2
Tbio
Family:  Enzyme
Novelty:  0.05660996
Score:  0.908
Data Source:  STRINGDB
GCLM
Tbio
Family:  Enzyme
Novelty:  0.00395815
Score:  0.904
Data Source:  STRINGDB
Pathways (3)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Arginine and proline metabolism
KEGG
Glutathione metabolism
KEGG
Metabolic pathways
Name
Explore in Pharos
Explore in Source
Arginine and proline metabolism
Glutathione metabolism
Metabolic pathways
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
52.4
BMI-adjusted hip circumference
1
1
1
46.9
platelet crit
1
1
1
35
age-related hearing impairment
1
1
0
5.8
27.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
52.4
BMI-adjusted hip circumference
1
46.9
platelet crit
1
35
age-related hearing impairment
0
5.8
27.3
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine aminopeptidase 3
VGNC:625
461132
Macaque
leucine aminopeptidase 3
715081
Mouse
MGI:1914238
66988
Rat
RGD:1307985
289668
Dog
leucine aminopeptidase 3
VGNC:42582
479081
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine aminopeptidase 3
Macaque
leucine aminopeptidase 3
Mouse
Rat
Dog
leucine aminopeptidase 3
Publication Statistics
PubMed Score 307.71
PubMed score by year
PubTator Score 155.96
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title