Protein Summary
Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
- ENST00000226299
- ENSP00000226299
- ENSG00000002549
- ENST00000606142
- ENSP00000476028
- ENST00000618908
- ENSP00000481000
- LAPEP
- PEPS
- LAP
- PEPS
- LAPEP
- HEL-S-106
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 1 | ||
disease perturbation | 0.87 | ||
transcription factor binding site profile | 0.79 | ||
PubMedID | 0.77 | ||
kinase perturbation | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 307.71 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 218 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 307.71 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 218 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 30
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (30)
Protein-Protein Interactions (123)
Nearest Tclin Targets (2)
Upstream (1)
Downstream (1)
1 – 1 of 1
Pathways (3)
KEGG (3)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Arginine and proline metabolism | ||||
KEGG | Glutathione metabolism | ||||
KEGG | Metabolic pathways | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Arginine and proline metabolism | ||||
Glutathione metabolism | ||||
Metabolic pathways | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (3)
Components (7)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Non-traceable Author Statement (NAS) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
platelet count | 1 | 1 | 1 | 52.4 | |||||
BMI-adjusted hip circumference | 1 | 1 | 1 | 46.9 | |||||
platelet crit | 1 | 1 | 1 | 35 | |||||
age-related hearing impairment | 1 | 1 | 0 | 5.8 | 27.3 | ||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
platelet count | 1 | 52.4 | |||||
BMI-adjusted hip circumference | 1 | 46.9 | |||||
platelet crit | 1 | 35 | |||||
age-related hearing impairment | 0 | 5.8 | 27.3 | ||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | leucine aminopeptidase 3 | VGNC:625 | 461132 | |||||
Macaque | leucine aminopeptidase 3 | 715081 | ||||||
Mouse | MGI:1914238 | 66988 | ||||||
Rat | RGD:1307985 | 289668 | ||||||
Dog | leucine aminopeptidase 3 | VGNC:42582 | 479081 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | leucine aminopeptidase 3 | |||||
Macaque | leucine aminopeptidase 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | leucine aminopeptidase 3 | |||||
Publication Statistics
PubMed Score 307.71
PubMed score by year
PubTator Score 155.96
PubTator score by year
Related Publications
Text Mined References (26)
GeneRif Annotations (6)
Items per page:
0 of 0
PMID | Year | Title |
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