Tchem LANCL2 LanC-like protein 2

Protein Summary

Description

Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes.

Uniprot Accession IDs

• Q9NS86
• B2R8D4
• Q6NSL4
• Q8TCQ3
• Q9BSR1

Gene Name

• LANCL2

Ensembl ID

• ENST00000254770
• ENSP00000254770
• ENSG00000132434

Symbol

• GPR69B
• TASP
• TASP
• GPR69B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
transcription factor perturbation	0.94
virus perturbation	0.79
transcription factor binding site profile	0.75
transcription factor	0.64

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.72   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 189   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.72   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (1)

Explore Active Ligands

1 – 1 of 1

CHEMBL3355910

LANCL2Tchem

pIC50 : 8.18

Protein-Protein Interactions (42)

Explore Interacting Targets

1 – 10 of 42

• See Interactions on String-DB

PAGE1

Tbio

Novelty:  0.02731969

p_int:  0.996649902

p_ni:  0.00314097

p_wrong:  0.000209129

Data Source:  BioPlex

MINDY3

Tbio

Novelty:  0.02865765

p_int:  0.996382089

p_ni:  0.00361791

p_wrong:  1e-9

Score:  0.545

Data Source:  BioPlex,STRINGDB

DOK2

Tbio

Novelty:  0.02651438

p_int:  0.995901872

p_ni:  0.004098126

p_wrong:  1e-9

Score:  0.787

Data Source:  BioPlex,STRINGDB

KCNJ5

Tchem

Family:  IC

Novelty:  0.00385775

p_int:  0.99356183

p_ni:  0.006321297

p_wrong:  0.000116873

Data Source:  BioPlex

LAIR2

Tbio

Novelty:  0.06117644

p_int:  0.98782543

p_ni:  0.012072814

p_wrong:  0.000101757

Data Source:  BioPlex

ATXN7L1

Tdark

Novelty:  0.43694835

p_int:  0.981374292

p_ni:  0.016557533

p_wrong:  0.002068175

Data Source:  BioPlex

ANKRD39

Tdark

Novelty:  8.68843298

p_int:  0.973650388

p_ni:  0.026309309

p_wrong:  0.000040303

Data Source:  BioPlex

MRPS18C

Tdark

Novelty:  0.42868428

p_int:  0.973049156

p_ni:  0.02693326

p_wrong:  0.000017584

Data Source:  BioPlex

PVR

Tbio

Novelty:  0.00215811

p_int:  0.959746687

p_ni:  0.040235741

p_wrong:  0.000017572

Data Source:  BioPlex

GMFG

Tbio

Novelty:  0.0893982

p_int:  0.959013146

p_ni:  0.040946425

p_wrong:  0.000040429

Score:  0.309

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (12)

Functions (6)

Components (4)

Processes (2)

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1 – 6 of 6

GO Term	Evidence	Assigned by
phosphatidylinositol-3-phosphate binding	Inferred from Direct Assay (IDA)	UniProtKB
phosphatidylinositol-4-phosphate binding	Inferred from Direct Assay (IDA)	UniProtKB
phosphatidylinositol-5-phosphate binding	Inferred from Direct Assay (IDA)	UniProtKB
ATP binding	Non-traceable Author Statement (NAS)	UniProtKB
GTP binding	Non-traceable Author Statement (NAS)	UniProtKB
catalytic activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (0)

No GWAS traits found

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Cell membrane
Complete proteome
Cytoplasm
Lipoprotein
Membrane
Myristate
Nucleus
Phosphoprotein
Polymorphism
Reference proteome

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cardiovascular system phenotype
renal/urinary system phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	LanC like 2	VGNC:7399	463936
Macaque	LanC like 2		704882
Mouse	LanC (bacterial lantibiotic synthetase component C)-like 2	MGI:1919085	71835
Rat	LanC like 2	RGD:1310809	362375
Dog	LanC like 2	VGNC:49916	483240

Species	Name	OMA	EggNOG	Inparanoid
Chimp	LanC like 2
Macaque	LanC like 2
Mouse	LanC (bacterial lantibiotic synthetase component C)-like 2
Rat	LanC like 2
Dog	LanC like 2

Publication Statistics

PubMed Score 23.72

PubMed score by year

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PubTator Score 24.24

PubTator score by year

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Related Publications

Text Mined References (20)

GeneRif Annotations (10)

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PMID	Year	Title