Tbio LANCL1 LanC-like protein 1

Protein Summary

Description

May play a role in EPS8 signaling. Binds glutathione. This gene encodes a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]

Uniprot Accession IDs

• O43813

Gene Name

• LANCL1

Ensembl ID

• ENST00000233714
• ENSP00000233714
• ENSG00000115365
• ENST00000431941
• ENSP00000397646
• ENST00000441020
• ENSP00000393323
• ENST00000443314
• ENSP00000388713
• ENST00000450366
• ENSP00000393597

Symbol

• GPR69A
• p40
• GPR69A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	0.99
transcription factor perturbation	0.96
molecular function	0.88
co-expressed gene	0.85

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.48   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 101   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.48   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (36)

Explore Interacting Targets

1 – 10 of 36

• See Interactions on String-DB

FIGN

Tbio

Family:  Enzyme

Novelty:  0.02804869

p_int:  0.999999995

p_ni:  3e-9

p_wrong:  2e-9

Score:  0.516

Data Source:  BioPlex,STRINGDB

DERA

Tbio

Family:  Enzyme

Novelty:  0.0079635

p_int:  0.999996225

p_ni:  0.000003775

Score:  0.226

Data Source:  BioPlex,STRINGDB

IPP

Tbio

Novelty:  0.12841634

p_int:  0.999994435

p_ni:  0.000005565

Score:  0.295

Data Source:  BioPlex,STRINGDB

ALDH16A1

Tdark

Family:  Enzyme

Novelty:  0.21880567

p_int:  0.999987159

p_ni:  0.000012841

Score:  0.228

Data Source:  BioPlex,STRINGDB

UBN2

Tbio

Novelty:  0.09777456

p_int:  0.999422624

p_ni:  0.000577374

p_wrong:  1e-9

Score:  0.523

Data Source:  BioPlex,STRINGDB

TBC1D9

Tbio

Novelty:  0.20059899

p_int:  0.99891006

p_ni:  0.001089765

p_wrong:  1.75e-7

Score:  0.692

Data Source:  BioPlex,STRINGDB

TBC1D9B

Tdark

Novelty:  0.66719861

p_int:  0.998703265

p_ni:  0.001296735

Score:  0.558

Data Source:  BioPlex,STRINGDB

MYO7A

Tbio

Novelty:  0.00314435

p_int:  0.960189819

p_ni:  0.000034848

p_wrong:  0.039775332

Score:  0.56

Data Source:  BioPlex,STRINGDB

STOM

Tbio

Novelty:  0.00459891

Score:  0.838

Data Source:  STRINGDB

EPS8

Tbio

Family:  Enzyme

Novelty:  0.01023541

Score:  0.647

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (10)

Functions (6)

Components (3)

Processes (1)

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1 – 6 of 6

GO Term	Evidence	Assigned by
glutathione binding	Inferred from Direct Assay (IDA)	UniProtKB
low-density lipoprotein particle receptor binding	Inferred from Direct Assay (IDA)	MGI
zinc ion binding	Inferred from Direct Assay (IDA)	UniProtKB
SH3 domain binding	Inferred from Physical Interaction (IPI)	UniProtKB
G protein-coupled receptor activity	Traceable Author Statement (TAS)	ProtInc
catalytic activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (4)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
creatinine measurement	EFO_0004518	1	1	1		55.2
glomerular filtration rate	EFO_0005208	1	1	1		54.4
body height	EFO_0004339	1	1	1		31.4
sex hormone-binding globulin measurement	EFO_0004696	1	1	1		15.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 4 of 4

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
creatinine measurement	EFO_0004518	1		55.2
glomerular filtration rate	EFO_0005208	1		54.4
body height	EFO_0004339	1		31.4
sex hormone-binding globulin measurement	EFO_0004696	1		15.8

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Cell membrane
Complete proteome
Cytoplasm
Direct protein sequencing
Membrane
Metal-binding
Reference proteome
Zinc

GWAS Trait Find Similar Targets

No Header	No Header
body height
creatinine measurement
glomerular filtration rate
sex hormone-binding globulin measurement

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
homeostasis/metabolism phenotype
immune system phenotype
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	LanC like 1	VGNC:6367	459917
Mouse	LanC (bacterial lantibiotic synthetase component C)-like 1	MGI:1336997	14768
Rat	LanC like 1	RGD:69416	114515
Dog	LanC like 1	VGNC:42580	478897
Horse	LanC like 1	VGNC:19578	100050050

Species	Name	OMA	EggNOG	Inparanoid
Chimp	LanC like 1
Mouse	LanC (bacterial lantibiotic synthetase component C)-like 1
Rat	LanC like 1
Dog	LanC like 1
Horse	LanC like 1

Publication Statistics

PubMed Score 17.48

PubMed score by year

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PubTator Score 10.04

PubTator score by year

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Related Publications

Text Mined References (11)

GeneRif Annotations (2)

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10

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PMID	Year	Title