Tbio LAMTOR5 Ragulator complex protein LAMTOR5

Protein Summary

Description

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication. This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O43504
• Q6IBD8

Gene Name

• LAMTOR5

Ensembl ID

• ENST00000602318
• ENSP00000473439
• ENSG00000134248

Symbol

• HBXIP
• XIP
• XIP
• HBXIP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.87
biological process	0.76
transcription factor binding site profile	0.73
cellular component	0.68
kinase perturbation	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 276.12   (req: < 5)

Gene RIFs: 55   (req: <= 3)

Antibodies: 131   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 276.12   (req: >= 5)

Gene RIFs: 55   (req: > 3)

Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (118)

Explore Interacting Targets

1 – 10 of 118

• See Interactions on String-DB

RRAGA

Tbio

Novelty:  0.02022668

p_int:  0.999999983

p_ni:  1e-9

p_wrong:  1.6e-8

Score:  0.999

Data Source:  BioPlex,STRINGDB

RRAGD

Tbio

Novelty:  0.04742375

p_int:  0.999999936

p_ni:  6.4e-8

Score:  0.999

Data Source:  BioPlex,STRINGDB

ITPA

Tbio

Family:  Enzyme

Novelty:  0.00235169

p_int:  0.999999905

p_ni:  9.5e-8

Data Source:  BioPlex

SLC38A9

Tbio

Family:  Transporter

Novelty:  0.0879703

p_int:  0.999996127

p_ni:  0.000002762

p_wrong:  0.000001111

Score:  0.999

Data Source:  BioPlex,STRINGDB

LAMTOR4

Tdark

Novelty:  0.24218646

p_int:  0.999994887

p_ni:  0.000005109

p_wrong:  5e-9

Score:  0.999

Data Source:  BioPlex,STRINGDB

RRAGC

Tbio

Novelty:  0.01462756

p_int:  0.999993852

p_ni:  0.000006148

Score:  0.999

Data Source:  BioPlex,STRINGDB

UBP1

Tbio

Family:  TF

Novelty:  0.01140885

p_int:  0.999988787

p_ni:  0.000011191

p_wrong:  2.3e-8

Data Source:  BioPlex

LAMTOR2

Tbio

Novelty:  0.05210182

p_int:  0.999976012

p_ni:  0.000023988

Score:  0.999

Data Source:  BioPlex,STRINGDB

BORCS5

Tdark

Novelty:  0.59333419

p_int:  0.999969107

p_ni:  0.000030888

p_wrong:  5e-9

Data Source:  BioPlex

STK38

Tchem

Family:  Kinase

Novelty:  0.03242123

p_int:  0.999942954

p_ni:  0.000057045

p_wrong:  1e-9

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (18)

Reactome (16)

KEGG (1)

PathwayCommons (1)

Autophagy (R-HSA-9612973)

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1 – 5 of 16

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Autophagy	109 targets	R-HSA-9612973
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897
Reactome	Energy dependent regulation of mTOR by LKB1-AMPK	28 targets	R-HSA-380972
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436

Name	Explore in Pharos	Explore in Source
Autophagy	109 targets	R-HSA-9612973
Cellular responses to external stimuli	487 targets	R-HSA-8953897
Energy dependent regulation of mTOR by LKB1-AMPK	28 targets	R-HSA-380972
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (14)

Components (4)

Processes (10)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
cytosol	Inferred from Direct Assay (IDA)	UniProtKB
lysosome	Inferred from Direct Assay (IDA)	UniProtKB
Ragulator complex	Inferred from Direct Assay (IDA)	UniProtKB
lysosomal membrane	Traceable Author Statement (TAS)	Reactome

Disease Associations (null)

No disease associations found

GWAS Traits (2)

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5

1 – 2 of 2

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean reticulocyte volume	EFO_0010701	1	1	1		44.2
mean corpuscular volume	EFO_0004526	1	1	1		40.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 2 of 2

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean reticulocyte volume	EFO_0010701	1		44.2
mean corpuscular volume	EFO_0004526	1		40.7

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Lysosome
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
mean corpuscular volume
mean reticulocyte volume

MGI Phenotype Find Similar Targets

No Header	No Header
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	VGNC:8351	457120
Mouse	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	MGI:1915826	68576
Rat	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	RGD:1305005	295357
Horse	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	VGNC:19577	106783217
Cow	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5		516090

Species	Name	OMA	EggNOG	Inparanoid
Chimp	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
Mouse	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
Rat	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
Horse	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
Cow	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5

Publication Statistics

PubMed Score 276.12

PubMed score by year

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PubTator Score 51.51

PubTator score by year

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Related Publications

Text Mined References (64)

GeneRif Annotations (55)

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PMID	Year	Title