You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
LAMTOR5
Ragulator complex protein LAMTOR5

Protein Summary
Description
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. Down-regulates hepatitis B virus (HBV) replication. This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000602318
  • ENSP00000473439
  • ENSG00000134248

Symbol
  • HBXIP
  • XIP
  • XIP
  • HBXIP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
biological process
0.76
transcription factor binding site profile
0.73
cellular component
0.68
kinase perturbation
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 276.12   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 276.12   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (118)
RRAGA
Tbio
Novelty:  0.02022668
p_int:  0.999999983
p_ni:  1e-9
p_wrong:  1.6e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
RRAGD
Tbio
Novelty:  0.04742375
p_int:  0.999999936
p_ni:  6.4e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
ITPA
Tbio
Family:  Enzyme
Novelty:  0.00235169
p_int:  0.999999905
p_ni:  9.5e-8
Data Source:  BioPlex
SLC38A9
Tbio
Family:  Transporter
Novelty:  0.0879703
p_int:  0.999996127
p_ni:  0.000002762
p_wrong:  0.000001111
Score:  0.999
Data Source:  BioPlex,STRINGDB
LAMTOR4
Tdark
Novelty:  0.24218646
p_int:  0.999994887
p_ni:  0.000005109
p_wrong:  5e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
RRAGC
Tbio
Novelty:  0.01462756
p_int:  0.999993852
p_ni:  0.000006148
Score:  0.999
Data Source:  BioPlex,STRINGDB
UBP1
Tbio
Family:  TF
Novelty:  0.01140885
p_int:  0.999988787
p_ni:  0.000011191
p_wrong:  2.3e-8
Data Source:  BioPlex
LAMTOR2
Tbio
Novelty:  0.05210182
p_int:  0.999976012
p_ni:  0.000023988
Score:  0.999
Data Source:  BioPlex,STRINGDB
BORCS5
Tdark
Novelty:  0.59333419
p_int:  0.999969107
p_ni:  0.000030888
p_wrong:  5e-9
Data Source:  BioPlex
STK38
Tchem
Family:  Kinase
Novelty:  0.03242123
p_int:  0.999942954
p_ni:  0.000057045
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Energy dependent regulation of mTOR by LKB1-AMPK
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Energy dependent regulation of mTOR by LKB1-AMPK
Gene expression (Transcription)
Generic Transcription Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
44.2
mean corpuscular volume
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
44.2
mean corpuscular volume
1
40.7
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
VGNC:8351
457120
Mouse
MGI:1915826
68576
Rat
RGD:1305005
295357
Horse
late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
VGNC:19577
106783217
Cow
late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
516090
Species
Name
OMA
EggNOG
Inparanoid
Chimp
late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
Mouse
Rat
Horse
late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
Cow
late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
Publication Statistics
PubMed Score 276.12
PubMed score by year
PubTator Score 51.51
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title