Tbio LAMP3 Lysosome-associated membrane glycoprotein 3

Protein Summary

Description

May play a role in dendritic cell function and in adaptive immunity. Dendritic cells (DCs) are the most potent antigen-presenting cells. Immature DCs efficiently capture antigens and differentiate into interdigitating dendritic cells (IDCs) in lymphoid tissues that induce primary T-cell responses (summary by de Saint-Vis et al., 1998 [PubMed 9768752]).[supplied by OMIM, Dec 2010]

Uniprot Accession IDs

• Q9UQV4
• D3DNS4
• O94781
• Q8NEC8
• LAMP-3

Gene Name

• LAMP3

Ensembl ID

• ENST00000265598
• ENSP00000265598
• ENSG00000078081

Symbol

• DCLAMP
• TSC403
• LAMP
• CD208
• DCLAMP
• LAMP-3
• TSC403
• DC LAMP
• DC-LAMP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
gene perturbation	0.81
small molecule perturbation	0.64
cellular component	0.57
PubMedID	0.56

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Membrane Trafficking Regulatory Protein / Lysosome-associated Membrane Glycoprotein 3

DTO Classes

Protein / Transporter / Membrane Trafficking Regulatory Protein / Lysosome-associated Membrane Glycoprotein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.76   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 498   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.76   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 498   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (96)

Explore Interacting Targets

1 – 10 of 96

• See Interactions on String-DB

GALNT4

Tbio

Family:  Enzyme

Novelty:  0.05200323

p_int:  0.999999679

p_ni:  3.21e-7

Data Source:  BioPlex

MARCH5

Tbio

Family:  Epigenetic

Novelty:  0.02702094

p_int:  0.999998858

p_ni:  9.1e-7

p_wrong:  2.33e-7

Data Source:  BioPlex

NEK6

Tchem

Family:  Kinase

Novelty:  0.02394134

p_int:  0.999998669

p_ni:  0.000001297

p_wrong:  3.4e-8

Score:  0.181

Data Source:  BioPlex,STRINGDB

HUS1

Tbio

Novelty:  0.00837493

p_int:  0.999909324

p_ni:  0.000090663

p_wrong:  1.3e-8

Data Source:  BioPlex

NEK7

Tchem

Family:  Kinase

Novelty:  0.02675561

p_int:  0.999900334

p_ni:  0.000099665

p_wrong:  1e-9

Data Source:  BioPlex

SEC14L1

Tbio

Novelty:  0.09562071

p_int:  0.999672003

p_ni:  0.000304663

p_wrong:  0.000023334

Data Source:  BioPlex

MAPK8

Tchem

Family:  Kinase

Novelty:  0.00055723

p_int:  0.999666294

p_ni:  0.000333691

p_wrong:  1.6e-8

Data Source:  BioPlex

ZRANB3

Tbio

Family:  Enzyme

Novelty:  0.00398767

p_int:  0.999631106

p_ni:  0.00030674

p_wrong:  0.000062154

Score:  0.211

Data Source:  BioPlex,STRINGDB

DOP1B

Tbio

Novelty:  0.14441699

p_int:  0.999463739

p_ni:  0.000536248

p_wrong:  1.3e-8

Score:  0.195

Data Source:  BioPlex,STRINGDB

INTS8

Tdark

Novelty:  0.03933008

p_int:  0.998829076

p_ni:  0.001170913

p_wrong:  1e-8

Score:  0.185

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

KEGG (1)

Find Similar Targets

Items per page:

5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Lysosome	123 targets	path:hsa04142

Name	Explore in Pharos	Explore in Source
Lysosome	123 targets	path:hsa04142

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (15)

Components (8)

Processes (7)

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Items per page:

10

1 – 8 of 8

GO Term	Evidence	Assigned by
early endosome	Inferred from Direct Assay (IDA)	ParkinsonsUK-UCL
intracellular membrane-bounded organelle	Inferred from Direct Assay (IDA)	HPA
perinuclear region of cytoplasm	Inferred from Direct Assay (IDA)	ParkinsonsUK-UCL
plasma membrane	Inferred from Direct Assay (IDA)	ParkinsonsUK-UCL
vesicle	Inferred from Direct Assay (IDA)	ParkinsonsUK-UCL
alveolar lamellar body membrane	Inferred from Sequence or structural Similarity (ISS)	ParkinsonsUK-UCL
lysosomal membrane	Traceable Author Statement (TAS)	ProtInc
integral component of membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Parkinson's disease	EFO_0002508	6	5	1	1.2	94.9
blood metabolite measurement	EFO_0005664	1	1	1		67.1
lymphocyte count	EFO_0004587	1	1	1		42.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Parkinson's disease	EFO_0002508	1	1.2	94.9
blood metabolite measurement	EFO_0005664	1		67.1
lymphocyte count	EFO_0004587	1		42.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Adaptive immunity
Complete proteome
Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Immunity
Lysosome
Membrane
Polymorphism

GWAS Trait Find Similar Targets

No Header	No Header
blood metabolite measurement
lymphocyte count
Parkinson's disease

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	lysosomal associated membrane protein 3	VGNC:14239	746899
Macaque	lysosomal associated membrane protein 3		574213
Mouse	lysosomal-associated membrane protein 3	MGI:2441659	239739
Rat	lysosomal-associated membrane protein 3	RGD:1307928	303801
Horse	lysosomal associated membrane protein 3	VGNC:19572	100058615

Species	Name	OMA	EggNOG	Inparanoid
Chimp	lysosomal associated membrane protein 3
Macaque	lysosomal associated membrane protein 3
Mouse	lysosomal-associated membrane protein 3
Rat	lysosomal-associated membrane protein 3
Horse	lysosomal associated membrane protein 3

Publication Statistics

PubMed Score 62.76

PubMed score by year

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PubTator Score 193.15

PubTator score by year

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Related Publications

Text Mined References (46)

GeneRif Annotations (35)

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10

0 of 0

PMID	Year	Title