LAMP3
Lysosome-associated membrane glycoprotein 3
Protein Summary
May play a role in dendritic cell function and in adaptive immunity. Dendritic cells (DCs) are the most potent antigen-presenting cells. Immature DCs efficiently capture antigens and differentiate into interdigitating dendritic cells (IDCs) in lymphoid tissues that induce primary T-cell responses (summary by de Saint-Vis et al., 1998 [PubMed 9768752]).[supplied by OMIM, Dec 2010]
- ENST00000265598
- ENSP00000265598
- ENSG00000078081
- DCLAMP
- TSC403
- LAMP
- CD208
- DCLAMP
- LAMP-3
- TSC403
- DC LAMP
- DC-LAMP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 1 | ||
gene perturbation | 0.81 | ||
small molecule perturbation | 0.64 | ||
cellular component | 0.57 | ||
PubMedID | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 68.09 (req: < 5)
Gene RIFs: 50 (req: <= 3)
Antibodies: 498 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 68.09 (req: >= 5)
Gene RIFs: 50 (req: > 3)
Antibodies: 498 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0