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Tbio
LAMP1
Lysosome-associated membrane glycoprotein 1

Protein Summary
Description
Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis. Acts as a receptor for Lassa virus protein. The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332556
  • ENSP00000333298
  • ENSG00000185896

Symbol
  • LAMPA
  • CD107a
  • LGP120
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
cellular component
0.98
interacting protein
0.98
kinase perturbation
0.98
transcription factor binding site profile
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1668.65   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 1259   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1668.65   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 1259   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (446)
STK17B
Tchem
Family:  Kinase
Novelty:  0.0420158
p_int:  0.999989527
p_ni:  0.000006822
p_wrong:  0.000003651
Score:  0.175
Data Source:  BioPlex,STRINGDB
SLC38A7
Tdark
Family:  Transporter
Novelty:  0.24353276
p_int:  0.999964617
p_ni:  0.000035383
Score:  0.261
Data Source:  BioPlex,STRINGDB
FZD7
Tchem
Family:  GPCR
Novelty:  0.00916448
p_int:  0.999916751
p_ni:  0.000083249
Score:  0.165
Data Source:  BioPlex,STRINGDB
RAB4A
Tbio
Family:  Enzyme
Novelty:  0.00423197
p_int:  0.998796671
p_ni:  0.001061256
p_wrong:  0.000142073
Score:  0.708
Data Source:  BioPlex,STRINGDB
FZD2
Tchem
Family:  GPCR
Novelty:  0.00774893
p_int:  0.997485575
p_ni:  0.002514425
Score:  0.22
Data Source:  BioPlex,STRINGDB
PLAA
Tchem
Family:  Enzyme
Novelty:  0.01164687
p_int:  0.996982699
p_ni:  0.003017301
Score:  0.183
Data Source:  BioPlex,STRINGDB
C4A
Tbio
Novelty:  0.00062793
p_int:  0.996151128
p_ni:  0.00384887
p_wrong:  2e-9
Score:  0.192
Data Source:  BioPlex,STRINGDB
LEMD3
Tbio
Novelty:  0.00579701
p_int:  0.966033656
p_ni:  0.033966344
Data Source:  BioPlex
LGALS1
Tchem
Novelty:  0.00106509
p_int:  0.959440339
p_ni:  0.040536074
p_wrong:  0.000023587
Score:  0.205
Data Source:  BioPlex,STRINGDB
ELP6
Tbio
Novelty:  0.01229878
p_int:  0.933119134
p_ni:  0.066870226
p_wrong:  0.00001064
Score:  0.179
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (24)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
5
8
9
99
platelet count
4
4
5
87.9
C-reactive protein measurement
4
2
4
73.8
blood protein measurement
1
1
1
73.6
mean corpuscular hemoglobin concentration
1
1
1
67.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
9
99
platelet count
5
87.9
C-reactive protein measurement
4
73.8
blood protein measurement
1
73.6
mean corpuscular hemoglobin concentration
1
67.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysosomal associated membrane protein 1
VGNC:7294
737954
Macaque
lysosomal associated membrane protein 1
697331
Mouse
MGI:96745
16783
Rat
RGD:2989
25328
Dog
lysosomal associated membrane protein 1
VGNC:42574
476995
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysosomal associated membrane protein 1
Macaque
lysosomal associated membrane protein 1
Mouse
Rat
Dog
lysosomal associated membrane protein 1
Publication Statistics
PubMed Score 1668.65
PubMed score by year
PubTator Score 609.16
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title