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Tbio
LAMB1
Laminin subunit beta-1

Protein Summary
Description
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of cerebral cortex. It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons. Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Lam ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222399
  • ENSP00000222399
  • ENSG00000091136

Symbol
  • CLM
  • LIS5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
trait
0.86
transcription factor perturbation
0.84
cell type or tissue
0.83
PubMedID
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.44   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 417   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.44   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 417   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (256)
SERPINA12
Tbio
Novelty:  0.00549132
p_int:  0.999900328
p_ni:  0.000099672
Score:  0.158
Data Source:  BioPlex,STRINGDB
TMEM126A
Tbio
Novelty:  0.11759225
p_int:  0.999725664
p_ni:  0.000274336
Data Source:  BioPlex
FAM9C
Tdark
Novelty:  0.86727989
p_int:  0.99874604
p_ni:  0.00125396
Data Source:  BioPlex
CDHR2
Tbio
Novelty:  0.09806551
p_int:  0.996186676
p_ni:  0.003813324
Data Source:  BioPlex
DEFA1
Tbio
Novelty:  0.01027492
p_int:  0.985073356
p_ni:  0.014926644
Score:  0.177
Data Source:  BioPlex,STRINGDB
COLEC12
Tbio
Novelty:  0.02882427
p_int:  0.98405673
p_ni:  0.015943267
p_wrong:  3e-9
Score:  0.566
Data Source:  BioPlex,STRINGDB
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.976660521
p_ni:  0.023339476
p_wrong:  3e-9
Score:  0.352
Data Source:  BioPlex,STRINGDB
LGALS9
Tchem
Novelty:  0.00381766
p_int:  0.965445425
p_ni:  0.034554574
p_wrong:  1e-9
Score:  0.518
Data Source:  BioPlex,STRINGDB
CRP
Tbio
Novelty:  0.00001517
p_int:  0.958093409
p_ni:  0.041906591
p_wrong:  1e-9
Data Source:  BioPlex
CD14
Tbio
Novelty:  0.00872424
p_int:  0.952840251
p_ni:  0.047159749
Data Source:  BioPlex
Pathways (38)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Degradation of the extracellular matrix
Reactome
Developmental Biology
Reactome
ECM proteoglycans
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Axon guidance
Degradation of the extracellular matrix
Developmental Biology
ECM proteoglycans
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
8
9
16
95.4
4
3
0
1.1
93.1
waist-hip ratio
2
2
2
73.9
BMI-adjusted waist circumference
2
7
10
66.1
1
1
0
1.1
18.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
16
95.4
0
1.1
93.1
waist-hip ratio
2
73.9
BMI-adjusted waist circumference
10
66.1
0
1.1
18.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
laminin subunit beta 1
702111
Mouse
MGI:96743
16777
Rat
RGD:1306311
298941
Dog
laminin subunit beta 1
VGNC:42567
475882
Horse
laminin subunit beta 1
VGNC:19565
100060360
Species
Name
OMA
EggNOG
Inparanoid
Macaque
laminin subunit beta 1
Mouse
Rat
Dog
laminin subunit beta 1
Horse
laminin subunit beta 1
Publication Statistics
PubMed Score 104.44
PubMed score by year
PubTator Score 70.34
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title