You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
LAMA4
Laminin subunit alpha-4

Protein Summary
Description
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric lamini ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368638
  • ENSP00000357627
  • ENSG00000112769
  • ENST00000453937
  • ENSP00000398226
  • ENST00000455073
  • ENSP00000408604

Symbol
  • LAMA3
  • CMD1JJ
  • LAMA4*-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
kinase perturbation
0.88
PubMedID
0.84
disease perturbation
0.74
protein domain
0.73


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.7   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 308   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.7   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 308   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (127)
BCAM
Tbio
Novelty:  0.01697541
p_int:  0.999999925
p_ni:  7.4e-8
Score:  0.252
Data Source:  BioPlex,STRINGDB
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.999998431
p_ni:  0.000001569
Score:  0.235
Data Source:  BioPlex,STRINGDB
MCAM
Tbio
Novelty:  0.00128524
p_int:  0.999997976
p_ni:  0.000002023
Score:  0.861
Data Source:  BioPlex,STRINGDB
LGALS9
Tchem
Novelty:  0.00381766
p_int:  0.999994866
p_ni:  0.000004862
p_wrong:  2.71e-7
Score:  0.219
Data Source:  BioPlex,STRINGDB
PILRA
Tbio
Novelty:  0.05154386
p_int:  0.999924269
p_ni:  0.000073681
p_wrong:  0.00000205
Score:  0.239
Data Source:  BioPlex,STRINGDB
HADHA
Tbio
Novelty:  0.00385746
p_int:  0.99956551
p_ni:  0.000427693
p_wrong:  0.000006797
Data Source:  BioPlex
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.999448433
p_ni:  0.000299591
p_wrong:  0.000251976
Data Source:  BioPlex
ITGA6
Tbio
Novelty:  0.00217985
Score:  0.957
Data Source:  STRINGDB
ITGB4
Tbio
Novelty:  0.00386461
Score:  0.955
Data Source:  STRINGDB
LAMB1
Tbio
Novelty:  0.0104285
Score:  0.955
Data Source:  Reactome,STRINGDB
Pathways (28)
ECM proteoglycans (R-HSA-3000178)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ECM proteoglycans
Reactome
Extracellular matrix organization
Reactome
Laminin interactions
Reactome
MET activates PTK2 signaling
Reactome
MET promotes cell motility
Name
Explore in Pharos
Explore in Source
ECM proteoglycans
Extracellular matrix organization
Laminin interactions
MET activates PTK2 signaling
MET promotes cell motility
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist circumference
1
3
3
67.4
BMI-adjusted waist circumference
1
2
2
66.6
waist-hip ratio
1
2
2
57.1
BMI-adjusted waist-hip ratio
1
2
2
57.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist circumference
3
67.4
BMI-adjusted waist circumference
2
66.6
waist-hip ratio
2
57.1
BMI-adjusted waist-hip ratio
2
57.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
laminin subunit alpha 4
VGNC:3366
462946
Macaque
laminin subunit alpha 4
696685
Mouse
MGI:109321
16775
Rat
RGD:1560062
309816
Dog
laminin subunit alpha 4
475034
Species
Name
OMA
EggNOG
Inparanoid
Chimp
laminin subunit alpha 4
Macaque
laminin subunit alpha 4
Mouse
Rat
Dog
laminin subunit alpha 4
Publication Statistics
PubMed Score 84.70
PubMed score by year
PubTator Score 44.45
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title